FB2024_04 , released June 25, 2024
Allele: Dmel\EMC71
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General Information
Symbol
Dmel\EMC71
Species
D. melanogaster
Name
FlyBase ID
FBal0357020
Feature type
allele
Associated gene
Dmel\EMC7
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Xiong et al., 2019)
Mutagen
CRISPR/Cas9
(Xiong et al., 2019)
Progenitor genotype
Cytology
Description

An InDel mutation, resulting in loss of 8bp and addition of 4bp in the CDS within the first exon of EMC7.

(Xiong et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2L:16,017,018..16,017,025 [-]
Inserted_sequence:

CTCA

Comment:

The 8-bp sequence, TCAGCTGC, is replaced with CTCA resulting in a frameshift. The deletion coordinates were determined from the reported junction sequences.

(Xiong et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      EMC71 whole-eye clones are viable. Electroretinograms show the expected prolonged depolarization afterpotential to blue light stimuli, as observed in controls.

      (Xiong et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      EMC71
      emc71
      (Xiong et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)