FlyBase Allele Report: Dmel\PEK[HMJ02063]

General Information

Symbol

Dmel\PEK^HMJ02063

Species

D. melanogaster

Name

FlyBase ID

FBal0281341

Feature type

allele

Associated gene

Dmel\PEK

Associated Insertion(s)

Carried in Construct

P{TRiP.HMJ02063}

Also Known As

UAS-PERK RNAi, Perk RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMJ02063}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMJ02063

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates prion disease

modeled by Hsap\PRNP^V129.UAS.att

(Myers et al., 2022)

ameliorates congenital disorder of glycosylation Ij

modeled by Alg7^HMC03443

(Dalton et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of PEK^HMJ02063 under the control of Scer\GAL4^109(2)80 does not significantly affect the total branch length of the dendritic arbor in class IV ddaC neurons in third instar larvae.

(Tsuyama et al., 2017)

Females heterozygous for PEK^HMJ02063 and MTD-Gal4 (consists of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed to PEK^HMJ02063 males results in: 67% hatching; non-maternal effect.

(Sopko et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

PEK^HMJ02063/Scer\GAL4^αTub84B.PL is a suppressor of decreased size | somatic clone | larval stage phenotype of Rer1^KO

(Paul et al., 2024)

PEK^HMJ02063/Scer\GAL4^αTub84B.PL is a suppressor of increased cell death | somatic clone | larval stage phenotype of Rer1^KO

(Paul et al., 2024)

PEK^HMJ02063, Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage phenotype of Hsap\PRNP^V129.UAS, Scer\GAL4^GMR.PU

(Myers et al., 2022)

PEK^HMJ02063, Scer\GAL4^109(2)80 is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^109(2)80, prel^UAS.Tag:HA

(Tsuyama et al., 2017)

PEK^HMJ02063, Scer\GAL4^en.PU is a suppressor of increased cell death | third instar larval stage phenotype of Dad1^GD1006, Scer\GAL4^en.PU

(Zhang et al., 2016)

PEK^HMJ02063, Scer\GAL4^en.PU is a suppressor of increased occurrence of cell division | third instar larval stage phenotype of Dad1^GD1006, Scer\GAL4^en.PU

(Zhang et al., 2016)

Phenotype Manifest In

Suppressor of

Statement

Reference

PEK^HMJ02063/Scer\GAL4^αTub84B.PL is a suppressor of wing disc | somatic clone phenotype of Rer1^KO

(Paul et al., 2024)

PEK^HMJ02063, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Hsap\PRNP^V129.UAS, Scer\GAL4^GMR.PU

(Myers et al., 2022)

PEK^HMJ02063, Scer\GAL4^109(2)80 is a suppressor | partially of abdominal dorsal multidendritic neuron ddaC | third instar larval stage phenotype of Scer\GAL4^109(2)80, prel^UAS.Tag:HA

(Tsuyama et al., 2017)

PEK^HMJ02063, Scer\GAL4^109(2)80 is a suppressor | partially of dendrite | third instar larval stage phenotype of Scer\GAL4^109(2)80, prel^UAS.Tag:HA

(Tsuyama et al., 2017)

PEK^HMJ02063, Scer\GAL4^en.PU is a suppressor of wing disc | third instar larval stage phenotype of Dad1^GD1006, Scer\GAL4^en.PU

(Zhang et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The shortening of the dendritic arbor in class IV ddaC neurons in third instar larvae expressing prel^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^109(2)80 is strongly mitigated by co-expression of PEK^HMJ02063.

(Tsuyama et al., 2017)

Co-expression of PEK^HMJ02063 suppresses the compensatory cell division (partially) and apoptosis induced by Scer\GAL4^en.PU-controlled expression of Dad1^GD1006 in third instar larval wing discs.

(Zhang et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

42499

y¹ v¹; P{TRiP.HMJ02063}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

PEK^HMJ02063

(Myers et al., 2022)

Perk[HMJ]

(Tsuyama et al., 2017)

perk^RNAi

(Zhao et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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