FB2024_03 , released June 25, 2024
Allele: Dmel\spictKK102281
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General Information
Symbol
Dmel\spictKK102281
Species
D. melanogaster
Name
FlyBase ID
FBal0259143
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Depending on the genetic background, the expression of spictKK102281 under the control of Scer\GAL4221 in larval ddaE neurons leads to defects in axon regeneration, shown by a significant decrease in axon length, but not in dendrite regeneration, shown by a similar dendrite number, at 96h after laser-induced severance, as compared to controls. These neuron show an apparently normal early response to injury, since the pool of growing microtubules (identified as fluorescent EB1 comets) shows the expected increase in number and the expected reversal of polarity at 24h after laser-induced severance, as compared to controls.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
spictKK102281
Name Synonyms
Secondary FlyBase IDs
    References (2)