FlyBase Allele Report: Scer\GAL4[peb-GAL4]

FB2024_04 , released June 25, 2024

FB2024_04 , released June 25, 2024

Allele: Scer\GAL4^peb-GAL4

General Information

Symbol

Scer\GAL4^peb-GAL4

Species

S. cerevisiae

Name

FlyBase ID

FBal0244361

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Also Known As

Pebbled-GAL4, peb-GAL4

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

Cytology

Description

Allele components

Component

Use(s)

Inserted element

Encoded product / tool

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

olfactory receptor neuron

(Hong et al., 2009)

olfactory receptor neuron

(Sakurai et al., 2009)

adult antennal lobe commissure

(Sakurai et al., 2009)

adult antennal lobe glomerulus

(Sakurai et al., 2009)

adult antennal lobe

(Sakurai et al., 2009)

Additional Information

Statement

Reference

Drives expression in all olfactory receptor neurons.

(FlyBase Curators, 2017)

ScerGAL4^peb-GAL4 is expressed in all olfactory receptor neurons during early development.

(Hong et al., 2009)

Marker for

Reflects expression of

(Hong et al., 2009, Sakurai et al., 2009)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal chemosensory behavior | adult stage | heat sensitive, with Scer\FLP1^ey.PN, Scer\GAL80^Or42b.PG, shi^{ts.FRT.stop.UAS}

(Gao et al., 2015)

abnormal chemosensory behavior | adult stage | heat sensitive, with Scer\FLP1^ey.PN, shi^{ts.FRT.stop.UAS}

(Gao et al., 2015)

abnormal locomotor behavior | adult stage | :heat sensitive | chemical conditional, with Scer\FLP1^ey.PN, Scer\GAL80^Or42b.PG, shi^{ts.FRT.stop.UAS}

(Gao et al., 2015)

abnormal locomotor behavior | adult stage | :heat sensitive | chemical conditional, with Scer\FLP1^ey.PN, shi^{ts.FRT.stop.UAS}

(Gao et al., 2015)

abnormal neuroanatomy, with Mmus\Wld^S.UAS

(Kazama et al., 2011)

abnormal neuroanatomy, with Ten-a^GD8834

(Hong et al., 2012)

abnormal neuroanatomy, with Ten-m^GD3620

(Hong et al., 2012)

abnormal neuroanatomy | adult stage, with Lrp4^GD14320

(Mosca et al., 2017)

abnormal neuroanatomy | adult stage, with Lrp4^JF01570

(Mosca et al., 2017)

abnormal neuroanatomy | adult stage, with Lrp4^JF01632

(Mosca et al., 2017)

abnormal neuroanatomy | adult stage, with Lrp4^KK101962

(Mosca et al., 2017)

abnormal neuroanatomy | adult stage, with Lrp4^{UAS.Tag:HA,Tag:FLAG}

(Mosca et al., 2017)

abnormal neuroanatomy | adult stage, with PlexA^VDRC.cUa

(Sweeney et al., 2007)

abnormal neuroanatomy | adult stage, with Srpk79D^GD2777

(Mosca et al., 2017)

abnormal neuroanatomy | adult stage, with stan^KK100512

(Arguello et al., 2021)

abnormal neuroanatomy | P-stage, with stan^KK100512

(Arguello et al., 2021)

abnormal neuroanatomy | pupal stage, with Sema2b^3'UTR.UAS

(Joo et al., 2013)

abnormal neuroanatomy | pupal stage, with Sema2b^3'UTR.UAS, Sema2b^f02042

(Joo et al., 2013)

abnormal neuroanatomy | pupal stage, with Sema2b^f02042/Sema2b^3'UTR.UAS

(Joo et al., 2013)

abnormal neuroanatomy | pupal stage, with Sema2b^{GFP,Tag:M(mCd8a)}, Sema2b^f02042

(Joo et al., 2013)

abnormal neurophysiology | adult stage, with Cam^KK109037

(Bahk and Jones, 2016)

abnormal smell perception | adult stage, with Lrp4^GD14320

(Mosca et al., 2017)

abnormal smell perception | adult stage, with Lrp4^JF01570

(Mosca et al., 2017)

abnormal smell perception | adult stage, with Lrp4^JF01632

(Mosca et al., 2017)

abnormal smell perception | adult stage, with Lrp4^KK101962

(Mosca et al., 2017)

abnormal smell perception | adult stage, with Srpk79D^GD2777

(Mosca et al., 2017)

increased mortality | adult stage | heat sensitive, with shi^1.UAS

(Gao et al., 2015)

lethal - all die before end of pupal stage, with Cam^KK109037

(Bahk and Jones, 2016)

Phenotype Manifest In

adult antennal lobe, with stan^KK100512

(Arguello et al., 2021)

adult olfactory receptor neuron, with Lrp4^GD14320

(Mosca et al., 2017)

adult olfactory receptor neuron, with Lrp4^JF01570

(Mosca et al., 2017)

adult olfactory receptor neuron, with Lrp4^JF01632

(Mosca et al., 2017)

adult olfactory receptor neuron, with Lrp4^KK101962

(Mosca et al., 2017)

adult olfactory receptor neuron, with Lrp4^{UAS.Tag:HA,Tag:FLAG}

(Mosca et al., 2017)

adult olfactory receptor neuron, with Sema2b^3'UTR.UAS

(Joo et al., 2013)

adult olfactory receptor neuron, with Sema2b^3'UTR.UAS, Sema2b^f02042

(Joo et al., 2013)

adult olfactory receptor neuron, with Sema2b^{GFP,Tag:M(mCd8a)}, Sema2b^f02042

(Joo et al., 2013)

adult olfactory receptor neuron, with Srpk79D^GD2777

(Mosca et al., 2017)

adult olfactory receptor neuron Ir75b, with stan^KK100512

(Arguello et al., 2021)

adult olfactory receptor neuron Or33c/85e, with PlexA^VDRC.cUa

(Sweeney et al., 2007)

adult olfactory receptor neuron Or42a, with PlexA^VDRC.cUa

(Sweeney et al., 2007)

adult olfactory receptor neuron Or46a, with PlexA^VDRC.cUa

(Sweeney et al., 2007)

antennal lobe | P-stage, with stan^KK100512

(Arguello et al., 2021)

cilium, with nompB^KK108656

(Kuzhandaivel et al., 2014)

large basiconic sensillum of antennal segment 3, with Cam^KK109037

(Bahk and Jones, 2016)

olfactory receptor neuron, with nompB^KK108656

(Kuzhandaivel et al., 2014)

presynaptic active zone | adult stage, with Lrp4^GD14320

(Mosca et al., 2017)

presynaptic active zone | adult stage, with Lrp4^JF01570

(Mosca et al., 2017)

presynaptic active zone | adult stage, with Lrp4^JF01632

(Mosca et al., 2017)

presynaptic active zone | adult stage, with Lrp4^KK101962

(Mosca et al., 2017)

presynaptic active zone | adult stage, with Lrp4^{UAS.Tag:HA,Tag:FLAG}

(Mosca et al., 2017)

presynaptic active zone | adult stage, with Srpk79D^GD2777

(Mosca et al., 2017)

synapse | adult stage, with Lrp4^GD14320

(Mosca et al., 2017)

synapse | adult stage, with Lrp4^JF01570

(Mosca et al., 2017)

synapse | adult stage, with Lrp4^JF01632

(Mosca et al., 2017)

synapse | adult stage, with Lrp4^KK101962

(Mosca et al., 2017)

synapse | adult stage, with Lrp4^{UAS.Tag:HA,Tag:FLAG}

(Mosca et al., 2017)

synapse | adult stage, with Srpk79D^GD2777

(Mosca et al., 2017)

Detailed Description

Statement

Reference

Inhibition (using shi^1.UAS at 33[o]C) of Scer\GAL4^peb-GAL4 cells in adult females results in lethality. Inhibition of a subset of Scer\GAL4^peb-GAL4 cells (using shi^{ts.FRT.stop.UAS} at 33[o]C with Scer\FLP1^ey.PN) in adult females significantly abolishes aversion to E2-hexenal and acetic acid, compared to controls; significant aversion is restored when expression is restricted to a smaller subset of cells using Scer\GAL80^Orco, Scer\GAL80^Ir64a.PA, Scer\GAL80^Or85a.PG or Scer\GAL80^Or22a.PG; significant aversion to acetic acid, but not E2-hexenal, is restored using Scer\GAL80^Or42b.PG.

(Gao et al., 2015)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^peb-GAL4, Ten-m^GD3620 has abnormal neuroanatomy phenotype, enhanceable by Scer\GAL4^peb-GAL4/Ten-a^GD8834

(Hong et al., 2012)

Scer\GAL4^peb-GAL4, Ten-a^GD8834 has abnormal neuroanatomy phenotype, enhanceable by Ten-m^GD3620/Scer\GAL4^peb-GAL4

(Hong et al., 2012)

PlexA^VDRC.cUa, Scer\GAL4^peb-GAL4 has abnormal neuroanatomy | adult stage phenotype, enhanceable by Sema1a^k13702/Sema-1a[+]

(Sweeney et al., 2007)

Suppressed by

Statement

Reference

Lrp4^GD14320, Scer\GAL4^peb-GAL4 has abnormal smell perception | adult stage phenotype, suppressible | partially by Srpk79D^UAS.Venus, Scer\GAL4^peb-GAL4

(Mosca et al., 2017)

Lrp4^KK101962, Scer\GAL4^peb-GAL4 has abnormal smell perception | adult stage phenotype, suppressible | partially by GABA-B-R2^RNAi.UAS, Scer\GAL4^peb-GAL4

(Mosca et al., 2017)

NOT suppressed by

Statement

Reference

Lrp4^KK101962, Scer\GAL4^peb-GAL4 has abnormal neuroanatomy | adult stage phenotype, non-suppressible by GABA-B-R2^RNAi.UAS, Scer\GAL4^peb-GAL4

(Mosca et al., 2017)

Scer\GAL4^peb-GAL4, Srpk79D^GD2777 has abnormal neuroanatomy | adult stage phenotype, non-suppressible by Lrp4^{UAS.Tag:HA,Tag:FLAG}, Scer\GAL4^peb-GAL4

(Mosca et al., 2017)

Enhancer of

Statement

Reference

Scer\GAL4^peb-GAL4/Ten-a^GD8834 is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^peb-GAL4, Ten-m^GD3620

(Hong et al., 2012)

Ten-m^GD3620/Scer\GAL4^peb-GAL4 is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^peb-GAL4, Ten-a^GD8834

(Hong et al., 2012)

Suppressor of

Statement

Reference

Srpk79D^P10036/Scer\GAL4^peb-GAL4 is a suppressor of abnormal neuroanatomy | adult stage phenotype of Lrp4^dalek

(Mosca et al., 2017)

Srpk79D^UAS.Venus, Scer\GAL4^peb-GAL4 is a suppressor | partially of abnormal smell perception | adult stage phenotype of Lrp4^GD14320, Scer\GAL4^peb-GAL4

(Mosca et al., 2017)

GABA-B-R2^RNAi.UAS, Scer\GAL4^peb-GAL4 is a suppressor | partially of abnormal smell perception | adult stage phenotype of Lrp4^KK101962, Scer\GAL4^peb-GAL4

(Mosca et al., 2017)

NOT Suppressor of

Statement

Reference

GABA-B-R2^RNAi.UAS, Scer\GAL4^peb-GAL4 is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of Lrp4^KK101962, Scer\GAL4^peb-GAL4

(Mosca et al., 2017)

Lrp4^{UAS.Tag:HA,Tag:FLAG}, Scer\GAL4^peb-GAL4 is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of Scer\GAL4^peb-GAL4, Srpk79D^GD2777

(Mosca et al., 2017)

Phenotype Manifest In

Enhanced by

Statement

Reference

PlexA^VDRC.cUa, Scer\GAL4^peb-GAL4 has maxillary palp olfactory receptor neuron phenotype, enhanceable by Sema1a^k13702/Sema-1a[+]

(Sweeney et al., 2007)

NOT suppressed by

Statement

Reference

Scer\GAL4^peb-GAL4, Srpk79D^GD2777 has adult olfactory receptor neuron phenotype, non-suppressible by Lrp4^{UAS.Tag:HA,Tag:FLAG}, Scer\GAL4^peb-GAL4

(Mosca et al., 2017)

Scer\GAL4^peb-GAL4, Srpk79D^GD2777 has synapse | adult stage phenotype, non-suppressible by Lrp4^{UAS.Tag:HA,Tag:FLAG}, Scer\GAL4^peb-GAL4

(Mosca et al., 2017)

Scer\GAL4^peb-GAL4, Srpk79D^GD2777 has presynaptic active zone | adult stage phenotype, non-suppressible by Lrp4^{UAS.Tag:HA,Tag:FLAG}, Scer\GAL4^peb-GAL4

(Mosca et al., 2017)

Lrp4^KK101962, Scer\GAL4^peb-GAL4 has adult olfactory receptor neuron phenotype, non-suppressible by GABA-B-R2^RNAi.UAS, Scer\GAL4^peb-GAL4

(Mosca et al., 2017)

Lrp4^KK101962, Scer\GAL4^peb-GAL4 has synapse | adult stage phenotype, non-suppressible by GABA-B-R2^RNAi.UAS, Scer\GAL4^peb-GAL4

(Mosca et al., 2017)

Lrp4^KK101962, Scer\GAL4^peb-GAL4 has presynaptic active zone | adult stage phenotype, non-suppressible by GABA-B-R2^RNAi.UAS, Scer\GAL4^peb-GAL4

(Mosca et al., 2017)

Suppressor of

Statement

Reference

Srpk79D^P10036/Scer\GAL4^peb-GAL4 is a suppressor of adult olfactory receptor neuron phenotype of Lrp4^dalek

(Mosca et al., 2017)

Srpk79D^P10036/Scer\GAL4^peb-GAL4 is a suppressor of synapse | adult stage phenotype of Lrp4^dalek

(Mosca et al., 2017)

Srpk79D^P10036/Scer\GAL4^peb-GAL4 is a suppressor of presynaptic active zone | adult stage phenotype of Lrp4^dalek

(Mosca et al., 2017)

NOT Suppressor of

Statement

Reference

Lrp4^{UAS.Tag:HA,Tag:FLAG}, Scer\GAL4^peb-GAL4 is a non-suppressor of adult olfactory receptor neuron phenotype of Scer\GAL4^peb-GAL4, Srpk79D^GD2777

(Mosca et al., 2017)

Lrp4^{UAS.Tag:HA,Tag:FLAG}, Scer\GAL4^peb-GAL4 is a non-suppressor of synapse | adult stage phenotype of Scer\GAL4^peb-GAL4, Srpk79D^GD2777

(Mosca et al., 2017)

Lrp4^{UAS.Tag:HA,Tag:FLAG}, Scer\GAL4^peb-GAL4 is a non-suppressor of presynaptic active zone | adult stage phenotype of Scer\GAL4^peb-GAL4, Srpk79D^GD2777

(Mosca et al., 2017)

GABA-B-R2^RNAi.UAS, Scer\GAL4^peb-GAL4 is a non-suppressor of adult olfactory receptor neuron phenotype of Lrp4^KK101962, Scer\GAL4^peb-GAL4

(Mosca et al., 2017)

GABA-B-R2^RNAi.UAS, Scer\GAL4^peb-GAL4 is a non-suppressor of synapse | adult stage phenotype of Lrp4^KK101962, Scer\GAL4^peb-GAL4

(Mosca et al., 2017)

GABA-B-R2^RNAi.UAS, Scer\GAL4^peb-GAL4 is a non-suppressor of presynaptic active zone | adult stage phenotype of Lrp4^KK101962, Scer\GAL4^peb-GAL4

(Mosca et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^peb-GAL4/Toll-7^UAS.cYa rescues Df(2R)Toll-7^AW1

(Ward et al., 2015)

Sema2b^{GFP,Tag:M(mCd8a)}/Scer\GAL4^peb-GAL4 rescues Sema2b^f02042

(Joo et al., 2013)

Sema2b^3'UTR.UAS/Scer\GAL4^peb-GAL4 rescues Sema2b^f02042

(Joo et al., 2013)

PlexB^UAS.cHa/Scer\GAL4^peb-GAL4 rescues PlexB^KG00878

(Joo et al., 2013)

Fails to rescue

Scer\GAL4^peb-GAL4/Wnt5^UAS.cFa fails to rescue Wnt5^unspecified

(Wu et al., 2014)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

80570

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Scer\GAL4^peb-GAL4

Name Synonyms

Secondary FlyBase IDs

References (50)

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