UASt regulatory sequences drive expression of an inverted repeat.
30 day old flies expressing foxoKK108485 under the control of Scer\GAL4Myo31DF-NP0001 in the enterocytes show a significant reduction in the numbers of commensal bacteria in the gut compared to age-matched controls. Intestinal stem cell proliferation is significantly reduced in the 30 day old mutant flies compared to controls.
Expression of foxoKK108485 in enterocytes under the control of Scer\GAL80ts.αTub84B and Scer\GAL4Myo31DF-NP0001 results in a significant increase in lipid levels in the whole animal.
Scer\GAL4Cg.PA/foxoKK108485 is a suppressor of abnormal starvation stress response | recessive | adult stage phenotype of RelE20
Scer\GAL4sNPF-R.2.5/foxoKK108485 is a suppressor of abnormal feeding behavior | adult stage phenotype of Scer\GAL4sNPF-R.2.5, mnbUAS.cHa
foxoKK108485, Scer\GAL4fln.IFM is a non-suppressor of flightless | progressive phenotype of LamCG489V.UAS, Scer\GAL4fln.IFM
foxoKK108485, Scer\GAL4fln.IFM is an enhancer of indirect flight muscle cell | adult stage phenotype of LamCG489V.UAS, Scer\GAL4fln.IFM
foxoKK108485, Scer\GAL4fln.IFM is an enhancer of nucleus | adult stage phenotype of LamCG489V.UAS, Scer\GAL4fln.IFM
foxoKK108485, Scer\GAL4fln.IFM is an enhancer of myofibril | adult stage phenotype of LamCG489V.UAS, Scer\GAL4fln.IFM
Scer\GAL4Cg.PA/foxoKK108485 is a suppressor of adult fat body | nutrition conditional phenotype of RelE20
foxoKK108485, Scer\GAL4fln.IFM is a non-suppressor of indirect flight muscle cell | adult stage phenotype of LamCR205W.UAS, Scer\GAL4fln.IFM
foxoKK108485, Scer\GAL4fln.IFM is a non-suppressor of wing phenotype of LamCG489V.UAS, Scer\GAL4fln.IFM
The co-expression of LamCUAS.cSa and foxoKK108485 under the control of Scer\GAL4fln.IFM does not lead to any obvious indirect flight muscle, wing posture or flight defects.
30 day adults co-expressing foxoKK108485 and PGRP-SC2Scer\UAS.cGa under the control of Scer\GAL4Myo31DF-NP0001 in the enterocytes do not show a reduction in intestinal stem cell proliferation compared to age-matched controls.
The increase in food consumption compared to controls seen in adults expressing mnbScer\UAS.cHa under the control of Scer\GAL4sNPF-R.2.5 is suppressed by co-expression of foxoKK108485.