FlyBase Allele Report: Dmel\park[KK107919]

General Information

Symbol

Dmel\park^KK107919

Species

D. melanogaster

Name

FlyBase ID

FBal0235254

Feature type

allele

Associated gene

Dmel\park

Associated Insertion(s)

Carried in Construct

P{KK107919}

Also Known As

UAS-parkin RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK107919}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK107919

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Parkinson's disease 2

CEC

(Cornelissen et al., 2018)

CEA

(Valadas et al., 2018)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 2

modeled by Chchd2^S81L.UAS

(Baek et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal flight, with Scer\GAL4^Tub.PU

(Zanon et al., 2017)

male semi-fertile, with Scer\GAL4^Tub.PU

(Zanon et al., 2017)

visible, with Scer\GAL4^Tub.PU

(Zanon et al., 2017, Sen et al., 2015)

Phenotype Manifest In

thorax, with Scer\GAL4^Tub.PU

(Zanon et al., 2017)

wing, with Scer\GAL4^Tub.PU

(Zanon et al., 2017, Sen et al., 2015)

Detailed Description

Statement

Reference

The expression of park^KK107919 under the control of Scer\GAL4^Tub.PU induces wing posture defects in a high proportion of individuals, thorax indentations in a significant proportion of individuals, a significant decrease in flight performance, and a severe decrease in the progeny of males, as compared to controls.

(Zanon et al., 2017)

Expression of park^KK107919 driven by Scer\GAL4^tub.PU significantly increases abnormal wing posture compared to controls.

(Sen et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^Tub.PU, park^KK107919 has visible phenotype, enhanceable by Stoml2^GD16706/Scer\GAL4^Tub.PU

(Zanon et al., 2017)

Scer\GAL4^Tub.PU, park^KK107919 has visible phenotype, enhanceable by Atg1^GD7149, Scer\GAL4^Tub.PU

(Sen et al., 2015)

Scer\GAL4^Tub.PU, park^KK107919 has visible phenotype, enhanceable by clu^KK108024/Scer\GAL4^Tub.PU

(Sen et al., 2015)

Scer\GAL4^Tub.PU, park^KK107919 has visible phenotype, enhanceable by clu^GD13926/Scer\GAL4^Tub.PU

(Sen et al., 2015)

Scer\GAL4^Tub.PU, park^KK107919 has visible phenotype, enhanceable by Pink1^RNAi.UAS.cYa, Scer\GAL4^Tub.PU

(Sen et al., 2015)

NOT Enhanced by

Statement

Reference

Scer\GAL4^Tub.PU, park^KK107919 has abnormal flight phenotype, non-enhanceable by Stoml2^GD16706/Scer\GAL4^Tub.PU

(Zanon et al., 2017)

Scer\GAL4^Tub.PU, park^KK107919 has male semi-fertile phenotype, non-enhanceable by Stoml2^GD16706/Scer\GAL4^Tub.PU

(Zanon et al., 2017)

Suppressed by

Statement

Reference

Scer\GAL4^Tub.PU, park^KK107919 has abnormal flight phenotype, suppressible by Hsap\STOML2^UAS.cZa, Scer\GAL4^Tub.PU

(Zanon et al., 2017)

Scer\GAL4^Tub.PU, park^KK107919 has male semi-fertile phenotype, suppressible by Hsap\STOML2^UAS.cZa, Scer\GAL4^Tub.PU

(Zanon et al., 2017)

Scer\GAL4^Tub.PU, park^KK107919 has visible phenotype, suppressible by Hsap\STOML2^UAS.cZa, Scer\GAL4^Tub.PU

(Zanon et al., 2017)

Scer\GAL4^Tub.PU, park^KK107919 has abnormal flight phenotype, suppressible by Scer\GAL4^Tub.PU/Stoml2^UAS.cZa

(Zanon et al., 2017)

Scer\GAL4^Tub.PU, park^KK107919 has male semi-fertile phenotype, suppressible by Scer\GAL4^Tub.PU/Stoml2^UAS.cZa

(Zanon et al., 2017)

Scer\GAL4^Tub.PU, park^KK107919 has visible phenotype, suppressible by Scer\GAL4^Tub.PU/Stoml2^UAS.cZa

(Zanon et al., 2017)

Enhancer of

Statement

Reference

Scer\GAL4^Tub.PU/park^KK107919 is an enhancer of visible phenotype of Scer\GAL4^Tub.PU, Stoml2^GD16706

(Zanon et al., 2017)

Scer\GAL4^en-e16E/park^KK107919 is an enhancer of increased cell death | third instar larval stage phenotype of Scer\GAL4^en-e16E, vtd^GL00522

(Liu et al., 2016)

Scer\GAL4^Tub.PU/park^KK107919 is an enhancer of visible phenotype of Scer\GAL4^Tub.PU, clu^KK108024

(Sen et al., 2015)

park^KK107919, Scer\GAL4^Mhc.PW is an enhancer of visible phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW

(Sen et al., 2015)

Scer\GAL4^Tub.PU/park^KK107919 is an enhancer of visible phenotype of Scer\GAL4^Tub.PU, clu^GD13926

(Sen et al., 2015)

NOT Enhancer of

Statement

Reference

Scer\GAL4^Tub.PU/park^KK107919 is a non-enhancer of abnormal flight phenotype of Scer\GAL4^Tub.PU, Stoml2^GD16706

(Zanon et al., 2017)

Scer\GAL4^Tub.PU/park^KK107919 is a non-enhancer of male semi-fertile phenotype of Scer\GAL4^Tub.PU, Stoml2^GD16706

(Zanon et al., 2017)

Suppressor of

Statement

Reference

park^KK107919, Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage | progressive phenotype of Chchd2^S81L.UAS, Scer\GAL4^GMR.PU

(Baek et al., 2021)

NOT Suppressor of

Statement

Reference

park^KK107919, Scer\GAL4^Mef2.PR is a non-suppressor of increased mortality phenotype of Mterf4^NIG.15390R, Scer\GAL4^Mef2.PR

(Shan et al., 2024)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^Tub.PU, park^KK107919 has wing phenotype, enhanceable by Stoml2^GD16706/Scer\GAL4^Tub.PU

(Zanon et al., 2017)

Scer\GAL4^Tub.PU, park^KK107919 has thorax phenotype, enhanceable by Stoml2^GD16706/Scer\GAL4^Tub.PU

(Zanon et al., 2017)

Scer\GAL4^Tub.PU, park^KK107919 has wing phenotype, enhanceable by Atg1^GD7149, Scer\GAL4^Tub.PU

(Sen et al., 2015)

Scer\GAL4^Tub.PU, park^KK107919 has wing phenotype, enhanceable by clu^KK108024/Scer\GAL4^Tub.PU

(Sen et al., 2015)

Scer\GAL4^Tub.PU, park^KK107919 has wing phenotype, enhanceable by clu^GD13926/Scer\GAL4^Tub.PU

(Sen et al., 2015)

Scer\GAL4^Tub.PU, park^KK107919 has wing phenotype, enhanceable by Pink1^RNAi.UAS.cYa, Scer\GAL4^Tub.PU

(Sen et al., 2015)

Suppressed by

Statement

Reference

Scer\GAL4^Tub.PU, park^KK107919 has wing phenotype, suppressible by Scer\GAL4^Tub.PU/Stoml2^UAS.cZa

(Zanon et al., 2017)

Scer\GAL4^Tub.PU, park^KK107919 has thorax phenotype, suppressible by Scer\GAL4^Tub.PU/Stoml2^UAS.cZa

(Zanon et al., 2017)

Scer\GAL4^Tub.PU, park^KK107919 has wing phenotype, suppressible by Hsap\STOML2^UAS.cZa, Scer\GAL4^Tub.PU

(Zanon et al., 2017)

Scer\GAL4^Tub.PU, park^KK107919 has thorax phenotype, suppressible by Hsap\STOML2^UAS.cZa, Scer\GAL4^Tub.PU

(Zanon et al., 2017)

Enhancer of

Statement

Reference

Scer\GAL4^Tub.PU/park^KK107919 is an enhancer of wing phenotype of Scer\GAL4^Tub.PU, Stoml2^GD16706

(Zanon et al., 2017)

Scer\GAL4^Tub.PU/park^KK107919 is an enhancer of thorax phenotype of Scer\GAL4^Tub.PU, Stoml2^GD16706

(Zanon et al., 2017)

Scer\GAL4^en-e16E/park^KK107919 is an enhancer of wing disc | third instar larval stage phenotype of Scer\GAL4^en-e16E, vtd^GL00522

(Liu et al., 2016)

Scer\GAL4^Tub.PU/park^KK107919 is an enhancer of wing phenotype of Scer\GAL4^Tub.PU, clu^KK108024

(Sen et al., 2015)

park^KK107919, Scer\GAL4^Mhc.PW is an enhancer of wing phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW

(Sen et al., 2015)

Scer\GAL4^Tub.PU/park^KK107919 is an enhancer of wing phenotype of Scer\GAL4^Tub.PU, clu^GD13926

(Sen et al., 2015)

Suppressor of

Statement

Reference

park^KK107919, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Chchd2^S81L.UAS, Scer\GAL4^GMR.PU

(Baek et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

The wing posture defects, the thorax indentations, the decreased flight performance and the decreased progeny induced by the expression of park^KK107919 under the control of Scer\GAL4^Tub.PU are partially suppressed by the co-expression of Stoml2^UAS.cZa.

The wing posture defects, the thorax indentations, but not the decreased flight performance or the decreased progeny, induced by the expression of either park^KK107919 or Stoml2^GD16706 under the control of Scer\GAL4^Tub.PU become exacerbated upon their co-expression.

(Zanon et al., 2017)

The dramatic increase in apoptosis (visualized by [*]Casp3 or acridine orange staining) observed in larval wing discs upon expression of vtd^GL00522 driven by Scer\GAL4^en-e16E is increased further by co-expression of park^KK107919.

(Liu et al., 2016)

Co-expression of Pink1^{dsRNA.Scer\UAS} or Atg1^GD7149 or clu^GD13926 or clu^KK108024 increases the percentage of abnormal wing posture seen in flies with park^KK107919 driven by Scer\GAL4^tub.PU.

Co-expression of park^KK107919 increases the percentage of abnormal wing posture seen in flies with clu^KK108024 or clu^GD13926 driven by Scer\GAL4^tub.PU.

(Sen et al., 2015)

Xenogenetic Interactions

Statement

Reference

(Zanon et al., 2017)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v104363

P{KK107919}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

park^KK107919

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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