FB2024_04 , released June 25, 2024
Allele: Dmel\AcCoASf03474
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General Information
Symbol
Dmel\AcCoASf03474
Species
D. melanogaster
Name
FlyBase ID
FBal0188294
Feature type
allele
Associated gene
Dmel\AcCoAS
Associated Insertion(s)
PBac{WH}AcCoASf03474
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Kong et al., 2010)
Mutagen
piggyBac activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
PBac{WH}AcCoASf03474
Cytology
Description
Allele components
Component
Use(s)
Inserted element
PBac{WH}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  alcohol use disorder
      CEA
      (Kong et al., 2010)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes show no morphological or overt behavioural defects.

      AcCoASf03474 flies exhibit decreased ethanol-induced hyperactivity without altering ethanol sedation sensitivity or sedation tolerance compared to controls.

      AcCoASf03474 flies respond normally to external stimuli, such as the ethanol olfactory startle response, when naive, but show a markedly reduced startle response upon repeat exposure to ethanol.

      (Kong et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AcCoASf03474
      (Kong et al., 2010)
      f03474
      (Kong et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)