FlyBase Allele Report: Dmel\CycE[UAS.cUa]

General Information

Symbol

Dmel\CycE^UAS.cUa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Unknown

FlyBase ID

FBal0184257

Feature type

allele

Associated gene

Dmel\CycE

Associated Insertion(s)

Carried in Construct

P{UAS-CycE.U}

Also Known As

UAS-CycE, UAS-cyclinE

Key Links

Transgenic product class

wild_type

(Griffiths and Hidalgo, 2004)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Griffiths and Hidalgo, 2004)

Mutagen

in vitro construct

(Griffiths and Hidalgo, 2004)

Progenitor genotype

Carried in construct

P{UAS-CycE.U}

Cytology

Description

UAS regulatory sequences drive expression of CycE.

(Griffiths and Hidalgo, 2004)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

CycE

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurodegenerative disease

modeled by Zzzz\CAG^{127Q.UAS.Tag:HA}

(Dubey and Tapadia, 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^nub.PU

(Hevia et al., 2017)

increased cell death, with Scer\GAL4^elav.PLu

(Khurana et al., 2006)

Phenotype Manifest In

adult brain, with Scer\GAL4^elav.PLu

(Khurana et al., 2006)

tracheole | cell non-autonomous, with Scer\GAL4^tey-5053A

(Mortimer and Moberg, 2013)

wing, with Scer\GAL4^nub.PU

(Hevia et al., 2017)

Detailed Description

Statement

Reference

The expression of CycE^Scer\UAS.cUa under the control of Scer\GAL4^nub.PU leads to a small but significant decrease in wing size, as compared to controls.

(Hevia et al., 2017)

Expression of CycE^Scer\UAS.cUa under the control of Scer\GAL4^tey-5053A results in an increase in the number of tracheal branches that terminate on ventrolateral body wall muscle 12 compared to controls.

(Mortimer and Moberg, 2013)

Overexpression of CycE^Scer\UAS.cUa in the larval brain under the control of Scer\GAL4^insc-Mz1407 does not affect neuroblast number.

(Ouyang et al., 2011)

Expression of CycE^Scer\UAS.cUa in the developing tracheal system under the control of Scer\GAL4^btl.PS generates dorsal trunk breaks in 18% of embryos.

(Mortimer and Moberg, 2007)

Expression of CycE^Scer\UAS.cUa in the adult brain under the control of Scer\GAL4^elav.PLu results in neurodegeneration, and cell-cycle activation is also observed.

(Khurana et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

CycE^UAS.cUa, Scer\GAL4^Bx-MS1096 is a non-enhancer of visible phenotype of Scer\GAL4^Bx-MS1096, trbl^UAS.cGa

(Gawlinski et al., 2007)

Suppressor of

Statement

Reference

CycE^UAS.cUa, Scer\GAL4^ey.PH is a suppressor | partially of abnormal size phenotype of Scer\GAL4^ey.PH, lig^{R185C.UAS.UTR}

(Baumgartner et al., 2013)

Diap1^EP3723/CycE^UAS.cUa, Scer\GAL4^ey.PH is a suppressor | partially of abnormal size phenotype of Scer\GAL4^ey.PH, lig^{R185C.UAS.UTR}

(Baumgartner et al., 2013)

CycE^UAS.cUa, Scer\GAL4^Bx-MS1096 is a suppressor of visible phenotype of Scer\GAL4^Bx-MS1096, Z600^UAS.cGa

(Gawlinski et al., 2007)

NOT Suppressor of

Statement

Reference

CycE^UAS.cUa, Scer\GAL4^nub.PU is a non-suppressor of abnormal size | adult stage phenotype of Scer\GAL4^nub.PU, Smox^NIG.2262R

(Hevia et al., 2017)

CycE^UAS.cUa, Scer\GAL4^Bx-MS1096 is a non-suppressor of visible phenotype of Scer\GAL4^Bx-MS1096, trbl^UAS.cGa

(Gawlinski et al., 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

CycE^UAS.cUa, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\MAPT^E14.UAS, Scer\GAL4^GMR.PF

(Khurana et al., 2006)

NOT Enhancer of

Statement

Reference

CycE^UAS.cUa, Scer\GAL4^Bx-MS1096 is a non-enhancer of wing phenotype of Scer\GAL4^Bx-MS1096, trbl^UAS.cGa

(Gawlinski et al., 2007)

Suppressor of

Statement

Reference

Diap1^EP3723/CycE^UAS.cUa, Scer\GAL4^ey.PH is a suppressor | partially of eye phenotype of Scer\GAL4^ey.PH, lig^{R185C.UAS.UTR}

(Baumgartner et al., 2013)

CycE^UAS.cUa, Scer\GAL4^ey.PH is a suppressor | partially of eye phenotype of Scer\GAL4^ey.PH, lig^{R185C.UAS.UTR}

(Baumgartner et al., 2013)

CycE^UAS.cUa, Scer\GAL4^insc-Mz1407 is a suppressor | partially of neuroblast phenotype of Scer\GAL4^insc-Mz1407, p53^UAS.Ex

(Ouyang et al., 2011)

CycE^UAS.cUa, Scer\GAL4^Bx-MS1096 is a suppressor of wing phenotype of Scer\GAL4^Bx-MS1096, Z600^UAS.cGa

(Gawlinski et al., 2007)

NOT Suppressor of

Statement

Reference

CycE^UAS.cUa, Scer\GAL4^nub.PU is a non-suppressor of wing phenotype of Scer\GAL4^nub.PU, Smox^NIG.2262R

(Hevia et al., 2017)

CycE^UAS.cUa, Scer\GAL4^insc-Mz1407 is a non-suppressor of neuroblast | third instar larval stage phenotype of Chro^KK105370, Scer\GAL4^insc-Mz1407

(Li et al., 2017)

Scer\GAL4^insc-Mz1407, p53^UAS.Ex, CycE^UAS.cUa is a non-suppressor of neuroblast | increased number | somatic clone phenotype of numb¹⁵

(Ouyang et al., 2011)

CycE^UAS.cUa, Scer\GAL4^Bx-MS1096 is a non-suppressor of wing phenotype of Scer\GAL4^Bx-MS1096, trbl^UAS.cGa

(Gawlinski et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of CycE^Scer\UAS.cUa does not suppress the decreased wing size induced by the expression of Smox^NIG.2262R under the control of Scer\GAL4^nub.PU.

(Hevia et al., 2017)

The reactivation defects in central brain neuroblasts (high proportion of the cells retain the cellular extensions, one of the hallmarks of the quiescent state) observed in third instar larvae expressing Chro^KK105370 under the control of Scer\GAL4^insc-Mz1407 cannot be rescued by co-expression of CycE^Scer\UAS.cUa.

(Li et al., 2017)

The small eye phenotype of Scer\GAL4^ey.PH lig^{R185C.Scer\UAS.UTR} flies is partially rescued by co-expression of th^EP3723 or CycE^Scer\UAS.cUa, and rescued further by co-expression of both th^EP3723 or CycE^Scer\UAS.cUa.

(Baumgartner et al., 2013)

Co-expression of CycE^Scer\UAS.cUa and p53^Scer\UAS.Ex generates a significant increase in ectopic neuroblasts in a numb¹⁵ mutant background, compared to overexpression of p53^Scer\UAS.Ex alone in a numb¹⁵ mutant background.

Co-expression of CycE^Scer\UAS.cUa can partially suppress the neuroblast-loss phenotype induced by overexpression of p53^Scer\UAS.Ex under the control of Scer\GAL4^insc-Mz1407.

(Ouyang et al., 2011)

Xenogenetic Interactions

Statement

Reference

The rough-eye phenotype observed in animals expressing Hsap\MAPT^E14.Scer\UAS under the control of Scer\GAL4^GMR.PF is enhanced by co-expression of CycE^Scer\UAS.cUa.

(Khurana et al., 2006)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CycE^Scer\UAS.cUa

CycE^UAS.cUa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Unknown

(Griffiths and Hidalgo, 2004)

Secondary FlyBase IDs

References (16)

Report Sections

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