FB2024_04 , released June 25, 2024
Allele: Dmel\DreddD55
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General Information
Symbol
Dmel\DreddD55
Species
D. melanogaster
Name
FlyBase ID
FBal0120963
Feature type
allele
Associated gene
Dmel\Dredd
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Leulier et al., 2000)
Mutagen
ethyl methanesulfonate
(Leulier et al., 2000)
Progenitor genotype
Cytology
Description

Amino acid replacement: W195term.

(Leulier et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:634,862..634,862 [-]
Nucleotide change:

G634862A

Amino acid change:

W173term | Dredd-PD; W173term | Dredd-PE; W173term | Dredd-PF; W119term | Dredd-PG

Reported amino acid change:

W195term

Comment:

Nonsense mutation (TGG to TAG) at Trp codon.

Comment:

The predicted amino acid change was reported relative to a 516aa Dredd protein, which would be created by the use of an uptream translation start. The current Dredd genome annotation uses a downstream AUG which is supported by both species conservation and RNA-seq data. The two start sites are 22 aa apart.

(Leulier, 2019.9.22, Leulier et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The programmed cell death of bursCCAP neurons seen in the adult ventral nerve cord of wild type flies after eclosion is strongly suppressed in DreddD55 mutant homozygotes.

      (Lee et al., 2013)

      DreddD55 homozygotes exhibit wild-type apoptosis of vCrz neurons, with no viable vCrz neurons detected at 7 hours after puparium formation.

      (Lee et al., 2011)

      Mutant flies that are infected with E. coli one day prior to infection with either X. nematophila or P. luminescens are highly susceptible to infection by either X. nematophila or P. luminescens (in contrast to wild-type flies which show increased survival after infection with either X. nematophila or P. luminescens due to partial protection by the prior infection with E. coli).

      (Aymeric et al., 2010)

      The proportion of DreddD55 homozygous pupae (24 hours APF) surviving to adulthood after UV irradiation (50,000 μJ/cm2) is significantly higher than for wild-type.

      (Georgel et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      DreddD55/DreddD55 is a non-suppressor of eye phenotype of Scer\GAL4GMR.PF, egrUAS.cMa

      (Moreno et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      DreddD55 PGRP-LBΔ double mutant adults infected with Erwinia carotovora carotovora by oral feeding exhibit an absence of immune response (immune deficiency pathway activation) in midgut and fat body compared to controls.

      (Charroux et al., 2018)

      Homozygosity for DreddD55 does not supress the ablation of adult eye tissue seen in egrScer\UAS.cMa; Scer\GAL4GMR.PF animals.

      (Moreno et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (15)