FlyBase Allele Report: Dmel\sog[YL26]

General Information

Symbol

Dmel\sog^YL26

Species

D. melanogaster

Name

FlyBase ID

FBal0046503

Feature type

allele

Associated gene

Dmel\sog

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Serpe et al., 2005)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with sog^P129D)

(Serpe et al., 2005)

lethal | recessive

(Serpe et al., 2005)

Phenotype Manifest In

posterior crossvein (with sog^P129D)

(Serpe et al., 2005)

Detailed Description

Statement

Reference

Only 31% of sog^P129D/sog^YL26 flies survive to adulthood. Of these, 15% exhibit partial loss of the posterior crossvein and the rest show more subtle alterations in which the posterior crossvein appears as a fragmented line.

(Serpe et al., 2005)

Double mutants of dpp^H48 with sog^YL26 or sog¹ have phenotypes identical to that of the dpp mutant alone.

(Holley et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

sog^YL26/sog^P129D is a suppressor of crossvein phenotype of tok^Δ2-41/tok^E1

(Serpe et al., 2005)

sog[+]/sog^YL26 is a suppressor | partially of crossvein phenotype of tok^Δ2-41/tok^E1

(Serpe et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

sog^YL26/+; tok^Δ2-41/tok^E1 escapers exhibit partial posterior crossveins with significantly more crossvein material than tok^Δ2-41/tok^E1 escapers. Further, crossveins are almost completely restored in sog^YL26/sog^P129D; tok^Δ2-41/tok^E1 animals.