FB2024_03 , released June 25, 2024
Allele: Dmel\sdE3
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General Information
Symbol
Dmel\sdE3
Species
D. melanogaster
Name
FlyBase ID
FBal0032670
Feature type
allele
Associated gene
Dmel\sd
Associated Insertion(s)
P{wE}sdE3
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
PM hybrid dysgenesis
P-element activity
(Inamdar et al., 1993, Campbell et al., 1991)
Progenitor genotype
Associated Insertion(s)
P{wE}sdE3
Cytology
Description

Insertion of a P{wE} element in an intron, approximately 5kb downstream of the transcription start site.

(Inamdar et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The phenotypic expressivity of the sdE3 mutant phenotype is background dependent.

      (Dworkin et al., 2009)

      Homozygotes/hemizygotes have scalloped wings.

      Heterozygotes show a direct effect on the shape of the wing, having an effect in the anterior region, but no effect in the posterior region.

      (Dworkin and Gibson, 2006)

      Homozygotes and hemizygotes show a reduced response to 1mM sucrose in a proboscis extension test when stimulated on the tarsal or labellar sensilla. Adults also show a reduced response to sucrose, and a normal preference but increased tolerance for salt in a feeding preference assay. The L1 neuron shows a normal response on stimulation of the labellar taste hairs with varying concentrations of sucrose, NaCl or KCl. Larvae show a reduced avoidance of NaCl and KCl in a chemotaxis test. Adults and larvae show a normal response to benzaldehyde and iso-amyl acetate in olfactory assays.

      (Inamdar et al., 1993)

      Wing phenotype.

      (Campbell et al., 1991)

      Similar wing phenotype to sd1.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The ability of bimd653 to act as an enhancer of the sdE3 mutant phenotype is background dependent.

      (Dworkin et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Hazelrigg.

      R. Levis.

      (Campbell et al., 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      E3
      (Dworkin and Gibson, 2006)
      sdE3
      (Dworkin et al., 2009)
      sdP[w+ry+E3]
      (Inamdar et al., 1993)
      sd[w+]
      (Lindsley and Zimm, 1992)
      sd[w,ryE]3
      sd[P(w,ry)E3]
      (Campbell et al., 1991)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)