FB2024_03 , released June 25, 2024
Allele: Dmel\ca1
Open Close
General Information
Symbol
Dmel\ca1
Species
D. melanogaster
Name
FlyBase ID
FBal0001461
Feature type
allele
Associated gene
Dmel\ca
Associated Insertion(s)
Carried in Construct
Also Known As
ca
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
Progenitor genotype
Cytology
Description

14bp deletion in the second coding exon that results in a frame shift after residue 194 and premature termination of translation after an additional 11 amino acids.

(Ma et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant flies show a significant decrease in ommochrome pigment levels and some reduction in drosopterin pigment levels compared to wild type.

      (Harris et al., 2011)

      Mutant flies have reduced red pigment in the eye compared to controls.

      (Cheli et al., 2010)

      The primary pigment cells in ca1 flies lack the large electron-lucent xanthommatin granules seen in wild type, while the granules in the secondary and tertiary pigment cells are fewer in number than normal and vary considerably in shape and density of their content. The small xanthommatin pigment granules seen in photoreceptor cells in wild-type animals appear to be normal in ca1 flies. and bwkΔ11 produces animals with an extra veins phenotype.

      (Ma et al., 2004)

      Considerable amounts of pigment are deposited in the eye but the ocelli remain colourless.

      (Tearle, 1991)

      Uptake of radio-labeled kynurenine by larval Malpighian tubules greatly reduced; uptake by developing eyes nearly normal.

      (Sullivan and Sullivan, 1975)

      Presence of 4-0-glucosyl-N-acetyldopamine, possibly a detoxification product of dopamine.

      (Okubo, 1958)

      Produce less v+ substance than wild type.

      (Clancy, 1942)

      Malpighian tubule colour: colourless.

      (Beadle, 1937)

      Eye color autonomous when larval optic disk from ca1 is transplanted into wild type or v hosts. Wild-type disk in ca1 not entirely autonomous.

      (Beadle and Ephrussi, 1936)

      RK1. Eye colour: ruby. Body slightly narrow; wings pointed.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      ca1 has abnormal eye color phenotype, non-enhanceable by Blos1ex2

      (Cheli et al., 2010)
      NOT suppressed by
      Statement
      Reference

      ca1 has abnormal eye color phenotype, non-suppressible by Blos1ex2

      (Cheli et al., 2010)
      Enhancer of
      Statement
      Reference

      ca1 is an enhancer of visible phenotype of Scer\GAL4GMR.PF, aosGD16463

      (Harris et al., 2011)

      ca1/ca[+] is an enhancer of visible phenotype of Scer\GAL4GMR.PF, bchsEP2299

      (Simonsen et al., 2007)
      Other
      Statement
      Reference

      ca1, cic1 has wild-type phenotype

      (Ma et al., 2004)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      ca1 has phenotype, non-suppressible by su(Hw)2

      (Lindsley and Grell, 1968)
      Enhancer of
      Statement
      Reference

      ca1 is an enhancer of eye phenotype of Scer\GAL4GMR.PF, aosGD16463

      (Harris et al., 2011)

      ca1/ca[+] is an enhancer of eye phenotype of Scer\GAL4GMR.PF, bchsEP2299

      (Simonsen et al., 2007)
      Other
      Statement
      Reference

      ca1, cicD49 has wing vein | ectopic phenotype

      (Ma et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The reduction in drosopterin pigment levels seen in flies carrying wdsRNA.GMR is enhanced manyfold if they are also mutant for ca1.

      The mispatterning of the eye caused by expression of aosGD16463 under the control of Scer\GAL4GMR.PF is enhanced in a ca1 background.

      (Harris et al., 2011)

      The reduced red eye pigment phenotype of ca1 blos1ex2 double mutants is indistinguishable from that of ca1 single mutants.

      (Cheli et al., 2010)

      The level of pteridine eye pigments in ltd1 ; ca1 double mutant flies resembles that seen in ca1 single mutants.

      (Ma et al., 2004)

      Eye colour: deep reddish yellow, with cn1. Eye colour: translucent brownish yellow, with bw1.

      (Mainx, 1938)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (2)
      Stocks (498)
      Notes on Origin
      Discoverer

      Bridges, 12th Dec. 1919.

      Comments
      Comments

      Mutant does not affect ncd function.

      (Yamamoto et al., 1989)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (36)