FB2024_02 , released April 23, 2024
Allele: Dmel\bw1
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General Information
Symbol
Dmel\bw1
Species
D. melanogaster
Name
FlyBase ID
FBal0001342
Feature type
allele
Associated gene
Dmel\bw
Associated Insertion(s)
412{}bw1
Carried in Construct
Also Known As
bw
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Dreesen et al., 1988)
Progenitor genotype
Associated Insertion(s)
412{}bw1
Cytology
Description

Known mutation in sequenced strain: complex mutation (multiple in-frame stops).

(FlyBase Curators, 2002-)

Insertion of DNA into the transcription unit.

(Dreesen et al., 1988)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  tauopathy
      modeled by Hsap\MAPTGMR.Ex.PJ
      (Ambegaokar and Jackson, 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      21-days old bw1 mutant adults raised at 29[o]C do not show significantly changes in PPL1 neurons, as compared to age-matched controls.

      (Cunningham et al., 2018)

      Sound-evoked compound action potentials in the antennal nerve are not significantly different from wild type in mutant flies. However, nonlinear mechanical amplification is significantly increased compared to wild type.

      (Senthilan et al., 2012)

      Mutant flies have significantly fewer synaptic vesicles in the terminals of the photoreceptor cells R1-R6 in the lamina. However, in contrast to the absolute numbers of synaptic vesicles, the profile density is not significantly different from wild type.

      (Borycz et al., 2008)

      Male heterozygous and homozygous bw1 flies have an increased resistance to the anesthetic enflurane compared to wild-type controls, as judged by climbing ability. This effect is true whether enflurane resistance is measured in regular light or red light. bw1 male flies show no increased resistance to the anesthetic halothane compared to wild-type flies when climbing ability is measured in regular light. However, bw1 mutants show increased sensitivity to this anesthetic when climbing ability is measured in red light.

      (Campbell and Nash, 2001)

      Affects the formation of drosopterins and reduces level of ommochrome in the eye.

      (Tearle, 1991)

      Red pigments lacking. Xanthommatin mostly replaced by dihydroxanthommatin. Pigment granules present but somewhat smaller than in wild type.

      (Phillips et al., 1973)

      Malpighian tubule colour: pale yellow. Testes colour: colourless.

      (Beadle, 1937)

      Eye colour: brown. Eye colour: light brownish wine on emergence, darkening to garnet. Eye colour: white, with cn1. Eye colour: white, with st1. Eye colour: white, with v1.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      bw1 has chemical resistant | dominant | male phenotype, non-enhanceable by st1

      (Campbell and Nash, 2001)
      NOT suppressed by
      Statement
      Reference

      bw1 has chemical resistant | dominant | male phenotype, non-suppressible by st1

      (Campbell and Nash, 2001)
      Enhancer of
      Statement
      Reference

      bw1/bw[+] is an enhancer of chemical sensitive phenotype of Gk1RNAi.UAS, Scer\GAL4c564

      (Wightman et al., 2012)
      Other
      Statement
      Reference

      In(2LR)Nella, bw1 has abnormal eye color phenotype

      (Henikoff et al., 1995)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      bw1 has phenotype, non-suppressible by su(Hw)2

      (Lindsley and Grell, 1968)
      Other
      Statement
      Reference

      In(2LR)Nella, bw1 has pigment cell phenotype

      (Henikoff et al., 1995)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The glycerol hypersensitivity of flies expressing GykdsRNA.Scer\UAS under the control of Scer\GAL4c564 (seen as a reduction in survival on a glycerol only food source) is enhanced if the flies are also heterozygous for bw1.

      (Wightman et al., 2012)

      The increased resistance of bw1 homozygous males to enflurane is not enhanced or suppressed by st1/st1. bw1/+, st1/+ males from bw1, st1 homozygous mothers show increased resistance to halothane when tested under red light and a slight increase in this resistance when tested under white light. A maternal effect is necessary for this phenotype as it is not seen in bw1/+, st1/+ males from bw1, st1 homozygous fathers.

      (Campbell and Nash, 2001)

      Eye colour: off-white, with In(2LR)Nella.

      (Henikoff et al., 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (2)
      Stocks (2,299)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Marker mutation present in the strain used in the genome sequencing project.

      (Misra et al., 2002)

      Eye color autonomous when transplanted into wild-type host.

      (Beadle and Ephrussi, 1936)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (38)