FB2024_03 , released June 25, 2024
Allele: Dmel\ac3
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General Information
Symbol
Dmel\ac3
Species
D. melanogaster
Name
FlyBase ID
FBal0000162
Feature type
allele
Associated gene
Dmel\ac
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Marcellini et al., 2005)
Mutagen
X ray
Progenitor genotype
Caused by aberration
In(1)ac3
Cytology
Description

Left breakpoint of In(1)ac3 at DNA coordinate +59 near the transcription start site of the ac.

(Campuzano et al., 1985)

Lesion maps to: 59.6 to 58.8 kb.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In ac3 flies, the following thoracic macrochaetae are missing: the posterior dorsocentral, the anterior dorsocentral and the posterior supra-alar. These flies also show a loss of microchaetae on the thorax posteriorly, laterally and centrally.

      (Marcellini et al., 2005)

      Homozygotes lack most microchaetae and some macrochaetae on the notum and legs.

      (Klein and Campos-Ortega, 1997)

      Sensory mother cells of bristles pSA, aDC and pDC are absent in the wing disc, but mitotically quiescent centers from which they emerge were present for aDC and pDC and showed no difference from wild type.

      (Usui and Kimura, 1992)

      No detectable ac protein accumulation. Removes the sc expression from the cells from which the ac-dependent pSA and DC bristles arise.

      (Skeath and Carroll, 1991)

      The total number of bristles on the basitarsi of the second legs is reduced. The number of bractless bristles on the basitarsi remains normal. Significantly more bristles are missing from the anterior side of the basitarsus than from the posterior side. One or the other of the distal sensilla is sometimes missing.

      (Held, 1990)

      Posterior and usually anterior dorsocentrals lacking; other bristles wild type. Hairs removed from areas across rear and front edges of thorax, through mid-dorsal area and between ocelli.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      ac3 has macrochaeta & leg phenotype, enhanceable by klu212lR63

      (Klein and Campos-Ortega, 1997)

      ac3 has microchaeta & leg phenotype, enhanceable by klu212lR63

      (Klein and Campos-Ortega, 1997)

      ac3 has macrochaeta & leg phenotype, enhanceable by kluP212

      (Klein and Campos-Ortega, 1997)

      ac3 has microchaeta & leg phenotype, enhanceable by kluP212

      (Klein and Campos-Ortega, 1997)

      ac3 has phenotype, enhanceable by emc[+]/emcD

      (Mari-Beffa et al., 1991)
      Suppressed by
      Statement
      Reference

      ac3 has phenotype, suppressible by su(sc)ru1

      (Georgiev and Gerasimova, 1992)

      ac3 has phenotype, suppressible by emc1/emc11

      (Mari-Beffa et al., 1991)
      NOT suppressed by
      Statement
      Reference

      ac3 has phenotype, non-suppressible by su(Hw)2

      (Lindsley and Grell, 1968)
      Suppressor of
      Statement
      Reference

      ac3 is a suppressor of phenotype of hry1

      (Sturtevant, 1970)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The ac3 phenotype is strongly enhanced if the flies are also homozygous for klu212lR63, and slightly enhanced if the flies are also homozygous for kluP212.

      (Klein and Campos-Ortega, 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      acsbm

      (Marcellini et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Dubinin, 1929.

      Comments
      Comments

      Transcript levels substantially reduced in both embryos and pupae; the l(1)sc transcript but not the sc transcript also reduced.

      (Campuzano et al., 1985)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      ac2
      ac3
      (Mari-Beffa et al., 1991)
      sc10
      sc11
      Name Synonyms
      Secondary FlyBase IDs
        References (23)