FB2024_04 , released June 25, 2024
Aberration: Dmel\Df(3R)E(spl)-rv27
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General Information
Symbol
Df(3R)E(spl)-rv27
Species
D. melanogaster
Name
FlyBase ID
FBab0010447
Feature type
chromosomal_deletion
Also Known As
Df(3R)E(spl)RA7.1, E(spl)RA7.1, Df(3R)E(spl)R-A7.1, E(spl)R-A7.1
Computed Breakpoints include

[<96F9];[>96F11]

Features within 96F9--96F11
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
E(spl)m8-HLH1
(Schrons et al., 1992, de Celis et al., 1991, Mari-Beffa et al., 1991, Ziemer et al., 1988, Knust et al., 1987)
Mutagen
X ray
(Schrons et al., 1992, Ziemer et al., 1988, Knust et al., 1987)
Class of aberration (relative to wild type)
chromosomal_deletion
Class of aberration (relative to progenitor)
chromosomal_deletion
(Schrons et al., 1992)
Breakpoints

[];[]

(Schrons et al., 1992)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 << m1 << gro << bk2

Genetic mapping information
Comments

34-kb deletion; -15 to +19 kb

Comments on Cytology

Cytologically invisible deletion. Cytologically normal (Knust et al., Dev Biol 122:262--273 ).

(Schrons et al., 1992)

Right limit of break 1 from inclusion of HLHm3 (FBrf0065591) Left limit of break 2 from inclusion of E(spl) (FBrf0056226)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations
    NOT in combination with other aberrations

    Df(3R)E(spl)-rv27 homozygotes and in combination with gro+t10.4 are lethal. Df(3R)E(spl)-rv27 gro+t10.4 clones display an increased microchaete density, occasionally two instead of the single macrochaete can be seen. Homozygous clones fail to differentiate bristles and form scars on the cuticle, sometimes associated with a few mutant epidermal hairs.

    (Heitzler et al., 1996)

    Clones extending to the wing margin in the posteior or anterior portion of the wing cause loss of margin tissue. Clones in the anterior compartment are accompanied by overgrowth and pattern duplication phenotypes.

    (de Celis et al., 1996)

    In a gro+t9.2 background, Df(3R)E(spl)-rv27/+ has no effect on the bristle loss phenotype of H20/HE31 while Df(3R)E(spl)-rv27/Df(3R)E(spl)-r72.1 suppresses the bristle loss phenotype.

    (Bang et al., 1995)

    In clones in the wing, the phenotype depends on where the clone lies. In the anterior compartment all clones abutting the wing margin cause local overgrowth and pattern duplications. Those abutting the wing margin and restricted to dorsal or ventral surfaces cause overgrowth of both dorsal and ventral cells. Clones at the wing margin cause loss of sensory organs and mild scalloping of the margin.

    (de Celis and Ruiz-Gomez, 1995)

    Hyperplasia of replicating sensory precursors: due to an increased number of ectodermal cells being recruited as sensory precursor cells.

    (Bodmer et al., 1993)

    Homozygotes exhibit a neurogenic phenotype: the entire neuroectoderm and the epidermal connections between the head and trunk are neuralised leaving only a small shield of dorsal epidermis. Transgenes encoding mutant versions of E(spl) and E(spl)m5-HLH reduce the severity of the neurogenic phenotype.

    (Tietze et al., 1993)

    Increase in SMCs per cluster in embryos lacking the maternal product.

    (Goriely et al., 1991)

    Lethal in combination with E(spl)1. Homozygotes have extreme neural hyperplasia and suppress the Nspl-1 phenotype.

    (Ziemer et al., 1988)

    Embryonic lethal and lethal in combination with E(spl)1. Homozygotes have extreme CNS and PNS hyperplasia due to low levels of E(spl)+ gene activity and suppress the Nspl-1 phenotype.

    (Knust et al., 1987)
    Stocks (0)
    Notes on Origin
    Discoverer

    Knust and Ziemer.

     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (11)
    Reported As
    Symbol Synonym
    Df(3R)E(spl)-rv27
    Df(3R)E(spl)A7.1
    (Godt et al., 1991)
    Df(3R)E(spl)R-A7.1
    (Schrons et al., 1992, Campos-Ortega and Knust, 1990)
    Df(3R)E(spl)RA-7.1
    (Tietze et al., 1993)
    Df(3R)E(spl)RA7.1
    (de Celis et al., 1996, Heitzler et al., 1996, de Celis and Ruiz-Gomez, 1995, Schrons et al., 1991)
    Df(3R)E(spl)R-A7.1
    (Bodmer et al., 1993, de Celis et al., 1993)
    E(spl)A7.1
    (Abmayr et al., 1992)
    E(spl)R-A7.1
    (Ziemer et al., 1988, Knust et al., 1987)
    E(spl)RA7.1
    (Bang et al., 1995, Sturtevant and Bier, 1995, de Celis et al., 1991)
    E(spl)RA71
    (Mari-Beffa et al., 1991)
    E(spl)rv27
    (Schrons et al., 1992)
    Name Synonyms
    Secondary FlyBase IDs
      References (19)