FB2024_03 , released April 23, 2024
FB2024_03 , released April 23, 2024
CV Term Report
Help Close All Open All
General Information
Term Ragulator complex ID (Ontology) GO:0071986 (Gene Ontology)
Definition A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified).[ PubMed:15989961 PubMed:16732272 PubMed:19177150 PubMed:19748353 PubMed:20381137 PubMed:22980980 PubMed:29199950 ]
Also Known As "MAPKSP1/ROBLD3/C11orf59 complex" ; "Rag GEF"
Comment
Links to Extrernal Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       5
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 Ragulator complex (all annotations which use CV term, excluding "NOT" statements)       1      5
     part_of | Ragulator complex       --       5
Spanning Tree (Parents/Children)
Only view relationship: 
vacuole
 |__vacuolar membrane__________________________
membrane                                       |
 |__membrane protein complex___________________|
protein-containing complex                     |
 |__membrane protein complex___________________|
bounding membrane of organelle                 |
 |__vacuolar membrane__________________________|
intracellular protein-containing complex       |
 |__guanyl-nucleotide exchange factor complex__|
                                               Ragulator complex  6 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a guanyl-nucleotide exchange factor complex
membrane protein complex
Part of vacuolar membrane
hide Synonyms & Secondary IDs
Synonyms
  • "EGO complex" RELATED
    "EGO-GSE complex" RELATED
    "GSE complex" RELATED
    "GTPase-containing complex for Gap1p sorting in the endosome" RELATED
    "MAPKSP1/ROBLD3/C11orf59 complex" EXACT
    "Rag GEF" EXACT
Secondary IDs
hide External Crossreferences & Linkouts