FB2024_04 , released June 25, 2024
FB2024_04 , released June 25, 2024
CV Term Report
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General Information
Term branched-chain alpha-keto acid dehydrogenase activity ID (Ontology) GO:0047101 (Gene Ontology)
Definition Catalysis of the reaction: [a branched-chain alpha-keto acid] + CoA + NAD+ = [a branched-chain acyl-CoA] + CO2 + NADH. This enzyme system catalyzes the oxidative decarboxylation of branched-chain alpha-keto acids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs.[ EC:1 ]
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       4
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Relevant FlyBase reports
 Gene Groups Genes
 branched-chain alpha-keto acid dehydrogenase activity (all annotations which use CV term, excluding "NOT" statements)       1      4
     contributes_to | branched-chain alpha-keto acid dehydrogenase activity       --       4
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  oxidoreductase activity, acting on the aldehyde or oxo group of donors
   |__oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
       |__branched-chain alpha-keto acid dehydrogenase activity  5 rec.
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Is a oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
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Synonyms
  • "2-oxoisovalerate dehydrogenase (acylating) activity" NARROW[ EC:1 ]
    "2-oxoisovalerate dehydrogenase activity" RELATED[ EC:1 ]
    "3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)" RELATED[ EC:1 ]
Secondary IDs
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EC:1.2.1.25
MetaCyc:1.2.1.25-RXN
MetaCyc:2KETO-4METHYL-PENTANOATE-DEHYDROG-RXN