FB2024_03 , released June 25, 2024
FB2024_03 , released June 25, 2024
CV Term Report
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General Information
Term PCNA complex ID (Ontology) GO:0043626 (Gene Ontology)
Definition A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.[ PubMed:12829735 ]
Also Known As "PCNA homotrimer" ; "proliferating cell nuclear antigen complex"
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       2
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 Genes
 PCNA complex (all annotations which use CV term, excluding "NOT" statements)       2
     part_of | PCNA complex       2
Spanning Tree (Parents/Children)
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nucleus
 |__nuclear protein-containing complex__________
protein-containing complex                      |
 |__nuclear protein-containing complex__________|
enzyme activator complex                        |
 |__DNA polymerase processivity factor complex__|
                                                PCNA complex  2 rec.
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Is a DNA polymerase processivity factor complex
nuclear protein-containing complex
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Synonyms
  • "PCNA homotrimer" EXACT
    "proliferating cell nuclear antigen complex" EXACT
    "sliding clamp" BROAD
Secondary IDs
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