General Information | |||
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Term | ERAD pathway | ID (Ontology) | GO:0036503 (Gene Ontology) |
Definition | The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.[ PubMed:20940304 PubMed:21969857 ] | ||
Also Known As | "endoplasmic reticulum-associated degradation" ; "protein degradation by ERAD" | ||
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response to organic substance |__response to organonitrogen compound____________ protein catabolic process | |__proteasomal protein catabolic process__________| cellular response to stress | |__response to endoplasmic reticulum stress_______| proteolysis involved in protein catabolic process | |__proteasomal protein catabolic process__________| response to nitrogen compound | |__response to organonitrogen compound____________| ERAD pathway 42 rec. |__maintenance of unfolded protein involved in ERAD pathway |__regulation of ERAD pathway 3 rec. | |__negative regulation of ERAD pathway 1 rec. | |__positive regulation of ERAD pathway 2 rec. |__retrograde protein transport, ER to cytosol 3 rec. | |__membrane protein proteolysis involved in retrograde protein transport, ER to cytosol | |__regulation of retrograde protein transport, ER to cytosol(+) 1 rec. |__ubiquitin-dependent glycoprotein ERAD pathway 3 rec. |__mannose trimming involved in glycoprotein ERAD pathway |
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Is a |
response to organonitrogen compound proteasomal protein catabolic process response to endoplasmic reticulum stress |
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