FB2024_03 , released June 25, 2024
FB2024_03 , released June 25, 2024
CV Term Report
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General Information
Term DSIF complex ID (Ontology) GO:0032044 (Gene Ontology)
Definition A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes.[ PubMed:12242279 PubMed:12653964 PubMed:12676794 PubMed:16581788 PubMed:19460865 ]
Also Known As "5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex" ; "DRB sensitivity inducing factor complex" ; "Spt4-Spt5 complex" (for all, see Synonyms field below)
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       2
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 Gene Groups Genes
 DSIF complex (all annotations which use CV term, excluding "NOT" statements)       1      2
     part_of | DSIF complex       --       2
Spanning Tree (Parents/Children)
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nucleoplasm_________________________
nuclear protein-containing complex__|
                                    transcription elongation factor complex
                                     |__DSIF complex  3 rec.
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Is a transcription elongation factor complex
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Synonyms
  • "5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex" EXACT
    "DRB sensitivity inducing factor complex" EXACT
    "Spt4-Spt5 complex" EXACT
    "Spt5-Spt4 complex" EXACT
Secondary IDs
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