FB2024_03 , released June 25, 2024
FB2024_03 , released June 25, 2024
CV Term Report
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General Information
Term endonuclease activity ID (Ontology) GO:0004519 (Gene Ontology)
Definition Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.[ ISBN:0198547684 ]
Comment
Links to Extrernal Ontologies
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       9
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 endonuclease activity (all annotations which use CV term, excluding "NOT" statements)       9
     enables | endonuclease activity       9
Spanning Tree (Parents/Children)
Only view relationship: 
  hydrolase activity, acting on ester bonds
   |__nuclease activity
       |__endonuclease activity  93 rec.
           |__DNA endonuclease activity 41 rec.
           |   |__DNA endonuclease activity, producing 3'-phosphomonoesters(+) 6 rec.
           |   |__double-stranded DNA endonuclease activity(+)
           |   |__endodeoxyribonuclease activity, producing 5'-phosphomonoesters(+) 13 rec.
           |   |__excinuclease ABC activity
           |   |__flap endonuclease activity(+) 8 rec.
           |   |__restriction endodeoxyribonuclease activity(+)
           |   |__retroviral 3' processing activity
           |   |__single-stranded DNA endodeoxyribonuclease activity(+) 15 rec.
           |   |__site-specific endodeoxyribonuclease activity, specific for altered base(+)
           |   |__T/G mismatch-specific endonuclease activity
           |__endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 9 rec.
           |   |__DNA endonuclease activity, producing 3'-phosphomonoesters(+) 6 rec.
           |   |__RNA endonuclease activity, producing 3'-phosphomonoesters(+) 3 rec.
           |__endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 34 rec.
           |   |__endodeoxyribonuclease activity, producing 5'-phosphomonoesters(+) 13 rec.
           |   |__RNA endonuclease activity, producing 5'-phosphomonoesters(+) 24 rec.
           |__RNA endonuclease activity 67 rec.
               |__endoribonuclease activity involved in viral induction of host mRNA catabolic process
               |__ribonuclease MRP activity 2 rec.
               |__ribonuclease T2 activity 2 rec.
               |__RNA endonuclease activity, producing 3'-phosphomonoesters(+) 3 rec.
               |__RNA endonuclease activity, producing 5'-phosphomonoesters(+) 24 rec.
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Reactome:R-HSA-5358512 "MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more"
Reactome:R-HSA-5358518 "MLH1:PMS2 makes single strand incision near 1-2 base mismatch"
Reactome:R-HSA-5690990 "5'- incision of DNA by ERCC1:ERCC4 in GG-NER"
Reactome:R-HSA-5693533 "DCLRE1C (ARTEMIS) processes DNA DSB ends"
Reactome:R-HSA-72180 "Cleavage of mRNA at the 3'-end"