FB2024_04 , released June 25, 2024
FB2024_04 , released June 25, 2024
CV Term Report
Help Close All Open All
General Information
Term cysteine-type endopeptidase activity ID (Ontology) GO:0004197 (Gene Ontology)
Definition Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
Also Known As "thiol endopeptidase activity"
Comment
Links to Extrernal Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      18
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 cysteine-type endopeptidase activity (all annotations which use CV term, excluding "NOT" statements)       1     18
     enables | cysteine-type endopeptidase activity       --      18
Spanning Tree (Parents/Children)
Only view relationship: 
peptidase activity
 |__endopeptidase activity____________
 |__cysteine-type peptidase activity__|
                                      cysteine-type endopeptidase activity  33 rec.
                                       |__calcium-dependent cysteine-type endopeptidase activity 7 rec.
                                       |__cysteine-type endopeptidase activity involved in apoptotic process 9 rec.
                                       |   |__cysteine-type endopeptidase activity involved in apoptotic signaling pathway 2 rec.
                                       |   |__cysteine-type endopeptidase activity involved in execution phase of apoptosis 6 rec.
                                       |__GPI-anchor transamidase activity 3 rec.
                                       |__ubiquitin-like protein-specific endopeptidase activity 2 rec.
                                           |__SUMO-specific endopeptidase activity 2 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a endopeptidase activity
cysteine-type peptidase activity
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "caspase activity" NARROW
    "lysosomal cysteine-type endopeptidase" NARROW
    "metacaspase activity" NARROW
    "thiol endopeptidase activity" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
EC:3.4.22.-
Reactome:R-HSA-114252 "Cleavage of Procaspase-3 by the apoptosome"
Reactome:R-HSA-114259 "Cleavage of Procaspase9 to caspase9"
Reactome:R-HSA-114261 "Cleavage of Procaspase-7 by the apoptosome"
Reactome:R-HSA-1236948 "Antigen processing by cathepsin S in endosoytic vesicle"
Reactome:R-HSA-139898 "Caspase-8 activates BID by cleavage"
Reactome:R-HSA-139952 "Caspase-8 processing in the DISC"
Reactome:R-HSA-1678920 "TLR processing at low pH"
Reactome:R-HSA-1678981 "TLR9 processing at neutral pH"
Reactome:R-HSA-201595 "Caspase-mediated cleavage of plakophilin-1"
Reactome:R-HSA-201603 "Caspase-mediated cleavage of PKC theta"
Reactome:R-HSA-201608 "Caspase-mediated cleavage of alpha adducin"
Reactome:R-HSA-201611 "Caspase-mediated cleavage of Rock-1"
Reactome:R-HSA-201622 "Caspase-mediated cleavage of gelsolin"
Reactome:R-HSA-201628 "Caspase-mediated cleavage of vimentin at DSVD (85)"
Reactome:R-HSA-201629 "Caspase-mediated cleavage of Tau"
Reactome:R-HSA-201630 "Caspase-mediated cleavage of Acinus"
Reactome:R-HSA-201631 "Caspase-mediated cleavage of Desmoglein 3"
Reactome:R-HSA-201634 "Caspase-mediated cleavage of FADK 1"
Reactome:R-HSA-201636 "Caspase-mediated cleavage of Desmoplakin"
Reactome:R-HSA-201637 "Caspase-mediated cleavage of plectin-1"
Reactome:R-HSA-201639 "Caspase-mediated cleavage of GAS2"
Reactome:R-HSA-201640 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha"
Reactome:R-HSA-2028692 "Cleavage of p-STK4 (p-MST1) by caspase 3"
Reactome:R-HSA-2028697 "Cleavage of p-STK3 (p-MST2) by caspase 3"
Reactome:R-HSA-202917 "Caspase-mediated cleavage of Desmoglein 1"
Reactome:R-HSA-202939 "Caspase-mediated cleavage of E-Cadherin"
Reactome:R-HSA-202947 "Caspase mediated cleavage of APC"
Reactome:R-HSA-202960 "Caspase mediated cleavage of C-IAP1"
Reactome:R-HSA-202966 "Caspase mediated cleavage of HIP-55"
Reactome:R-HSA-202967 "Caspase mediated cleavage of alpha-II-Fodrin"
Reactome:R-HSA-202969 "Caspase mediated cleavage of beta-catenin"
Reactome:R-HSA-211186 "Cleavage of DFF45 (224) by caspase-3"
Reactome:R-HSA-211190 "Caspase 3-mediated cleavage of DFF45 (117)"
Reactome:R-HSA-211651 "Cleavage of PAK-2 at 212"
Reactome:R-HSA-212552 "Caspase 3-mediated cleavage of PKC delta"
Reactome:R-HSA-2130336 "Initial proteolyis of Ii by aspartic proteases to lip22"
Reactome:R-HSA-2130349 "Generation of CLIP from lip10"
Reactome:R-HSA-2130504 "Cleavage of lip22 to lip10"
Reactome:R-HSA-2130706 "MHC class II antigen processing"
Reactome:R-HSA-2562564 "Caspase-8 processing within TLR4 complex"
Reactome:R-HSA-264865 "Caspase-mediated cleavage of Lamin A"
Reactome:R-HSA-264871 "Caspase-mediated cleavage of Lamin B1"
Reactome:R-HSA-3465448 "Caspase-8 and FLIP(L) processing at DISC"
Reactome:R-HSA-350158 "LGMN degrades GC"
Reactome:R-HSA-350318 "Caspase-mediated cleavage of vimentin at TNLD (429)"
Reactome:R-HSA-350319 "Caspase mediated cleavage of vimentin at IDVD (259)"
Reactome:R-HSA-350651 "Caspase-mediated cleavage of MASK"
Reactome:R-HSA-351849 "Caspase-mediated cleavage of Etk"
Reactome:R-HSA-351871 "Caspase-mediated cleavage of Z0-2"
Reactome:R-HSA-351876 "Caspase-mediated cleavage of occludin"
Reactome:R-HSA-351877 "Caspase-mediated cleavage of Desmoglein 2"
Reactome:R-HSA-351894 "Caspase mediated cleavage of BAP31"
Reactome:R-HSA-351901 "Caspase-mediated cleavage of MST3"
Reactome:R-HSA-351913 "Caspase-mediated cleavage of TJP1"
Reactome:R-HSA-351936 "Caspase-mediated cleavage of claspin"
Reactome:R-HSA-352268 "Cleavage of Satb1"
Reactome:R-HSA-418845 "Activation of caspase-3"
Reactome:R-HSA-418846 "Caspase cleavage of UNC5A"
Reactome:R-HSA-418852 "Caspase cleavage of UNC5B"
Reactome:R-HSA-448703 "Interleukin-1 family precursors are cleaved by caspase-1"
Reactome:R-HSA-5357828 "RIPK1 is cleaved by CASP8"
Reactome:R-HSA-5634228 "TRAF1 is cleaved by caspases"
Reactome:R-HSA-5660663 "Caspase-8 cleaves IL1B precursor"
Reactome:R-HSA-5681987 "LC3 is cleaved by ATG4"
Reactome:R-HSA-5682377 "LC3 de-lipidation by ATG4"
Reactome:R-HSA-6814387 "CASP14 cleaves filaggrin"
Reactome:R-HSA-9012556 "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37"
Reactome:R-HSA-9013895 "Caspase-8 processing within TLR3 complex"
Reactome:R-HSA-933532 "Processing of caspases"
Reactome:R-HSA-9603534 "Unknown caspase cleaves NTRK3"
Reactome:R-HSA-9647632 "CASP3 cleaves GSDME"
Reactome:R-HSA-9647680 "CASP1 cleaves GSDMD"
Reactome:R-HSA-9647999 "RCE1 cleaves S-Farn proRAS proteins"
Reactome:R-HSA-9684273 "3CLp cleaves pp1a"
Reactome:R-HSA-9684309 "3CLp cleaves nsp6-11"
Reactome:R-HSA-9684321 "nsp3 cleaves nsp1-4"
Reactome:R-HSA-9684336 "nsp1-4 cleaves itself"
Reactome:R-HSA-9684340 "3CLp cleaves pp1ab"
Reactome:R-HSA-9684351 "pp1a cleaves itself"
Reactome:R-HSA-9684352 "nsp3-4 cleaves itself"
Reactome:R-HSA-9686088 "CASP3 cleaves GSDMD"
Reactome:R-HSA-9686930 "RIPK3 is cleaved by CASP8"
Reactome:R-HSA-9693929 "RIPK1 variant is not cleaved by CASP8"
Reactome:R-HSA-9694338 "nsp1-4 cleaves itself"
Reactome:R-HSA-9694377 "pp1a cleaves itself"
Reactome:R-HSA-9694441 "3CLp cleaves pp1a"
Reactome:R-HSA-9694551 "3CLp cleaves nsp6-11"
Reactome:R-HSA-9694601 "nsp3-4 cleaves itself"
Reactome:R-HSA-9694625 "nsp3 cleaves nsp1-4"
Reactome:R-HSA-9694732 "3CLp cleaves pp1ab"
Reactome:R-HSA-9697750 "RIPK1 is cleaved by CASP8:FLIP(L)"
Reactome:R-HSA-9710101 "CASP4, CASP5 cleave GSDMD"
Reactome:R-HSA-9729704 "SARS-CoV-2 3CLpro dimer cleaves TAB1"
Reactome:R-HSA-9729730 "SARS-CoV-2 nsp3 cleaves IRF3"
Reactome:R-HSA-9729741 "SARS-CoV-2 3CLpro dimer cleaves NLRP12"