FB2024_03 , released April 23, 2024
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Reference
Citation
Jiao, J., Kavdia, K., Pagala, V., Palmer, L., Finkelstein, D., Fan, Y., Peng, J., Demontis, F. (2021). An age-downregulated ribosomal RpS28 protein variant regulates the muscle proteome.  G3 (Bethesda) 11(7): jkab165.
FlyBase ID
FBrf0254978
Publication Type
Research paper
Abstract
Recent evidence indicates that the composition of the ribosome is heterogeneous and that multiple types of specialized ribosomes regulate the synthesis of specific protein subsets. In Drosophila, we find that expression of the ribosomal RpS28 protein variants RpS28a and RpS28-like preferentially occurs in the germline, a tissue resistant to aging and that it significantly declines in skeletal muscle during aging. Muscle-specific overexpression of RpS28a at levels similar to those seen in the germline decreases early mortality and promotes the synthesis of a subset of proteins with known anti-aging roles, some of which have preferential expression in the germline. These findings indicate a contribution of specialized ribosomal proteins to the regulation of the muscle proteome during aging.
PubMed ID
PubMed Central ID
PMC8495913 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    G3 (Bethesda)
    Title
    G3 : genes - genomes - genetics
    ISBN/ISSN
    2160-1836
    Data From Reference
    Alleles (5)
    Genes (5)
    Natural transposons (1)
    Insertions (3)
    Experimental Tools (1)
    Transgenic Constructs (5)