FlyBase Gene Report: Dmel\FucTC

General Information

Symbol

Dmel\FucTC

Species

D. melanogaster

Name

alpha1,3-fucosyltransferase C

Annotation Symbol

CG40305

Feature Type

protein_coding_gene

FlyBase ID

FBgn0044872

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

20F3-20F3

Sequence location

X:23,008,766..23,011,303 [-]

Recombination map

1-66

RefSeq locus

NC_004354 REGION:23008766..23011303

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables alpha-(1->3)-fucosyltransferase activity

inferred from biological aspect of ancestor with PANTHER:PTN000231531

(GO Reference Genome Project, 2011-)

enables fucosyltransferase activity

inferred from sequence or structural similarity with HGNC:4017

(Fabini et al., 2001)

inferred from electronic annotation with InterPro:IPR001503

(InterPro Project Members, 2004-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in fucosylation

inferred from biological aspect of ancestor with PANTHER:PTN000231531

(GO Reference Genome Project, 2011-)

involved_in protein glycosylation

inferred from electronic annotation with InterPro:IPR001503

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR001503

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

ALPHA 1,3-FUCOSYLTRANSFERASES

Protein Family (UniProt)

Belongs to the glycosyltransferase 10 family. (P83088)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

ALPHA 1,3-FUCOSYLTRANSFERASES -: Alpha 1,3-fucosyltransferases catalyze the transfer of a fucose residue from the donor substrate, GDP-fucose, to an acceptor oligosaccharide, glycoprotein or glycolipid in an α-1,3-linkage. They are type II transmembrane Golgi-anchored proteins containing an N-terminal cytoplasmic tail, a transmembrane domain, and an extended stem region followed by a large globular C-terminal catalytic domain facing the Golgi lumen. (Adapted from PMID:16973733.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\FucTC for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P83088)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Mutation in sequenced strain: frameshift (-2).

Gene model reviewed during 5.54

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FucTC-RB

FBtr0299926

NM_001042855

2001

425

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FucTC-PB

FBpp0289204

49.1

425

6.50

P83088

NP_001036320

EAA46057

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P83088

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\FucTC using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FucTC_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.37

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\FucTC in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\FucTC

View exonic expression by tissue for Dmel\FucTC

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3355171/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0044872

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0044872

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0044872

Flygut - An atlas of the Drosophila adult midgut

FBgn0044872

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of FucTC

Transgenic constructs containing regulatory region of FucTC

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (8)

Hsap\FUT5

12 of 14

Yes

Hsap\FUT3

11 of 14

Yes

Hsap\FUT6

11 of 14

Hsap\FUT7

11 of 14

Yes

Hsap\FUT4

10 of 14

Hsap\FUT9

10 of 14

Yes

Hsap\FUT10

4 of 14

Hsap\FUT11

4 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (6)

Rnor\Fut7

12 of 14

Yes

Rnor\Fut4

11 of 14

Yes

Rnor\Fut9

11 of 14

Yes

Rnor\Fut11

4 of 14

Rnor\Fut10

3 of 14

Rnor\LOC367454

1 of 14

Yes

Mus musculus (laboratory mouse) (5)

Mmus\Fut4

11 of 14

Yes

Mmus\Fut7

11 of 14

Yes

Mmus\Fut9

11 of 14

Yes

Mmus\Fut10

4 of 14

Mmus\Fut11

4 of 14

Xenopus tropicalis (Western clawed frog) (14)

Xtro\fut5

8 of 13

Yes

Xtro\fut6.2

8 of 13

Yes

Xtro\fut6

8 of 13

Yes

Xtro\LOC100498016

8 of 13

Yes

7 of 13

7 of 13

7 of 13

5 of 13

3 of 13

3 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100497863

1 of 13

Xtro\trim33

1 of 13

Danio rerio (Zebrafish) (18)

Drer\fut7

11 of 14

Yes

Drer\fut9b.1

11 of 14

Yes

Drer\fut9b.3

11 of 14

Yes

Drer\fut9d

11 of 14

Yes

Drer\zgc:173737

11 of 14

Yes

Drer\ft1

10 of 14

Drer\ft2

10 of 14

Yes

Drer\fut9a

10 of 14

Yes

Drer\fut9b.6

10 of 14

Yes

Drer\si:ch1073-440p11.2

10 of 14

Drer\zgc:165582

9 of 14

Drer\fut9b.4

8 of 14

Yes

Drer\fut9b.5

8 of 14

Drer\LOC100150142

5 of 14

Yes

3 of 14

3 of 14

1 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\fut-1

11 of 14

Yes

Cele\fut-3

9 of 14

Yes

7 of 14

7 of 14

7 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP000365

12 of 12

Yes

Agam\AgaP_AGAP003191

5 of 12

Arabidopsis thaliana (thale-cress) (3)

Atha\FUT11

7 of 13

Yes

Atha\FUT12

7 of 13

Yes

Atha\FUT13

7 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:FucTC. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (3)

FucTA

9 of 13

FucTB

5 of 13

FucTD

5 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FUT5; fucosyltransferase 5

12 of 14

136835

FUT3; fucosyltransferase 3 (Lewis blood group)

11 of 14

111100

BLOOD GROUP, LEWIS SYSTEM; LE

FUT6; fucosyltransferase 6

11 of 14

136836

FUCOSYLTRANSFERASE 6 DEFICIENCY

FUT7; fucosyltransferase 7

11 of 14

602030

FUT4; fucosyltransferase 4

10 of 14

104230

FUT9; fucosyltransferase 9

10 of 14

606865

FUT10; fucosyltransferase 10

4 of 14

616931

FUT11; fucosyltransferase 11

4 of 14

616932

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

78296

DroID - A comprehensive database of gene and protein interactions.

FBgn0044872

MIST (protein-protein) - An integrated Molecular Interaction Database

3355171

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-66

Cytogenetic map

20F3-20F3

Sequence location

X:23,008,766..23,011,303 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

20F3-20F3

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

20A4-20A5

h26

(Drosophila Heterochromatin Genome Project, 2004)

Experimentally Determined Recombination Data

Location

1-66

(FlyBase, 2016)

1-66.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

44540

y¹ v¹; P{TRiP.HMC02935}attP40

86434

y¹ w^* TI{CRIMIC.TG4.0}FucTC^{CR01532-TG4.0}

65118

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03973}attP40

NIG-Fly

HMC02935

y¹ v¹; P{TRiP.HMC02935}attP40

VDRC

v330640

P{VSH330640}attP40

Genomic Clones (2)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (11)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP14278

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0044872

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CG40305) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: FucTC CG40305

(FlyBase, 1996-)

Additional comments

Source for merge of FucTC CG40305 was sequence comparison ( date:030820 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG40305

(Meadows, 2018.10.31, Yamamoto-Hino et al., 2015, Ni et al., 2010.12.1, Rendic et al., 2006)

FucTC

(Glittenberg et al., 2022, Gene Disruption Project members, 2018-, Ueda et al., 2018, Yamamoto-Hino et al., 2015, McNeil et al., 2011, Rendic et al., 2010, Rendic et al., 2006)

Name Synonyms

FucTC

alpha1,3-fucosyltransferase C

α1,3-fucosyltransferase

(Wilson, 2002)

Secondary FlyBase IDs

FBan0040305
FBgn0058305

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 33 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3355171

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P83088

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P83088

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P83088

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3355171/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0044872

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0044872

FlyMine - An integrated database for Drosophila genomics

FBgn0044872

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG40305

MARRVEL_MODEL - MARRVEL (model organism gene)

3355171

Linkouts

BioGRID - A database of protein and genetic interactions.

78296

DroID - A comprehensive database of gene and protein interactions.

FBgn0044872

DRSC - Results frm RNAi screens

FBgn0044872

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FucTC_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0044872

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0044872

Flygut - An atlas of the Drosophila adult midgut

FBgn0044872

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0044872

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

3355171

References (30)

The following external sites may use different assemblies or annotations than FlyBase.

-0.37

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