Elongator is a conserved 0.8-MDa protein complex composed of six subunits, Elp1-6, comprising two copies of each subunit arranged in two subcomplexes: Elp123 and Elp456. The catalytic subunit Elp3 harbours a conserved lysine acetyl-transferase (KAT) and a S-adenosyl-L-methionine (SAM) domain, which mediate acetylation and methylation, respectively. The main function of Elongator is the regulation of translation through targeted transfer-RNA modification. (Adapted from
FBrf0254982.)