Pyruvate dehydrogenases (acetyl-transferring) catalyze the conversion of pyruvate and a lipoamide to S-acetyldihydrolipoamide and CO[[2]]. Pyruvate dehydrogenase is a component, referred to as E1, of the pyruvate dehydrogenase complex, which includes additional components referred to as E2 and E3. Collectively E1-E3 transform pyruvate, NAD[+], coenzyme A into acetyl-CoA, CO2, and NADH. This conversion is crucial because acetyl-CoA may then be used in the citric acid cycle. (Adapted from https://en.wikipedia.org/wiki/Pyruvate_dehydrogenase.)
Notes on Group
Pdha1 and Pdha2 are paralogs: Pdha1 is expressed ubiquitously whereas Pdha2 is testis-specific.
Source Material
The
PYRUVATE DEHYDROGENASES (ACETYL-TRANSFERRING)
Gene Group has been compiled using the following publication(s):
Alonso et al., 2005
.
