Gene Group: UBIQUITIN TRANSFERASES

General Information

Name

UBIQUITIN TRANSFERASES

Species

D. melanogaster

Symbol

UBT

FlyBase ID

FBgg0001218

Date last reviewed

2019-07-25

Number of members

178

Description

Ubiquitin transferases catalyse the transfer of ubiquitin from one protein to another. They include ubiquitin-conjugating (E2) enzymes and ubiquitin ligase (E3) enzymes, which act sequentially to result in covalent attachment of ubiquitin to target proteins. Ubiquitination is required for many cellular processes, including protein degradation by the proteasome, cell cycle progression, transcriptional regulation, DNA repair and signal transduction. (Adapted from PMID:27015313.)

Notes on Group

Source Material

The UBIQUITIN TRANSFERASES Gene Group has been compiled using the following publication(s): Washington et al., 2020, Zavortink et al., 2020, Ji et al., 2014, Wisotzkey et al., 2014, Yamazaki et al., 2013, Darding and Meier, 2012, Vandenabeele and Bertrand, 2012, Du et al., 2011, Ying et al., 2011, Marin, 2010, Marin, 2010, Michelle et al., 2009, Rotin and Kumar, 2009, Rotin and Kumar, 2009, Sardiello et al., 2008, Eisenhaber et al., 2007, Jin and Harper, 2002, Jones et al., 2002, and Pham and Sauer, 2000 .

Key Gene Ontology (GO) terms

Molecular Function

ubiquitin-protein transferase activity

Biological Process

protein ubiquitination

Cellular Component

Related Gene Groups

Parent group(s)

UBIQUITIN-LIKE PROTEIN TRANSFERASES

Component group(s)

E2 UBIQUITIN CONJUGATING ENZYMES

E3 UBIQUITIN LIGASES

Other related group(s)

UBIQUITIN ACTIVATING ENZYMES

Members (178)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

E2 UBIQUITIN CONJUGATING ENZYMES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

ben

bendless

Ubc13, Bend, UbcD3

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

Bruce

BIR repeat containing ubiquitin-conjugating enzyme

dBruce, mod86

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009)

CG2574

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

CG2924

EG:25E8.2

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

CG3473

BG:DS01486.1

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

CG4502

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009)

CG5440

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

CG5823

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

CG7220

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

CG7656

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

CG8188

Ube2S

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

CG10254

BcDNA:LD22087

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009)

CG10862

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

CG14739

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

CG17030

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

CG40045

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009)

eff

effete

UbcD1, ms(3)88D, Ubc5, E(Pc)88D, UBC4

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

Taf1

TBP-associated factor 1

dTAF_II250, dTAF_II230, TAF_II250, Taf250, TAF_II230

(FlyBase, 2017-, Pham and Sauer, 2000)

Ubc2

Ubiquitin conjugating enzyme 2

UbcD2, l(2)k13206

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

Ubc4

Ubiquitin conjugating enzyme 4

UbcD4, E2

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

Ubc6

Ubiquitin conjugating enzyme 6

UbcD6, Dhr6, Rad6, dRad6

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

Ubc7

Ubiquitin conjugating enzyme 7

crl, courtless

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

Ubc10

Ubiquitin conjugating enzyme 10

UbcD10

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

Ubc84D

Ubiquitin conjugating enzyme 84D

ubc

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

Ubc87F

Ubiquitin conjugating enzyme 87F

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

UbcE2H

Ubiquitin conjugating enzyme E2H

Ubc-E2H, dUbc-E2H

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

vih

vihar

(FlyBase, 2017-, Du et al., 2011, Michelle et al., 2009, Jones et al., 2002)

GOLIATH UBIQUITIN LIGASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

gol

goliath

(FlyBase, 2017-, Yamazaki et al., 2013, Du et al., 2011, Ying et al., 2011)

gzl

godzilla E3 ubiquitin protein ligase

godzilla

(FlyBase, 2017-, Yamazaki et al., 2013, Du et al., 2011, Ying et al., 2011)

HECT UBIQUITIN LIGASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG3356

(FlyBase, 2017-, Du et al., 2011)

CG4238

(FlyBase, 2017-, Du et al., 2011)

CG5087

(FlyBase, 2017-, Du et al., 2011, Marin, 2010)

ctrip

circadian trip

(FlyBase, 2017-, Du et al., 2011)

Hecw

Hecw ubiquitin protein ligase

(FlyBase, 2017-, Du et al., 2011, Marin, 2010)

HERC2

HECT and RLD domain containing protein 2

(FlyBase, 2017-, Du et al., 2011, Marin, 2010)

Herc4

HECT and RLD domain containing E3 ubiquitin ligase 4

Sherpa

(FlyBase, 2017-, Du et al., 2011, Marin, 2010)

HUWE1

HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1

(FlyBase, 2017-, Du et al., 2011)

hyd

hyperplastic discs

l(3)c43, c43, UBR5

(FlyBase, 2017-, Du et al., 2011, Marin, 2010, Rotin and Kumar, 2009)

Nedd4

DNedd4

(FlyBase, 2017-, Du et al., 2011, Marin, 2010, Rotin and Kumar, 2009, Rotin and Kumar, 2009)

Smurf

SMAD specific E3 ubiquitin protein ligase

lack, dSmurf, lethal with a checkpoint kinase, Smurf1, dSmurf1

(FlyBase, 2017-, Du et al., 2011, Rotin and Kumar, 2009, Rotin and Kumar, 2009)

Su(dx)

Suppressor of deltex

(FlyBase, 2017-, Du et al., 2011, Rotin and Kumar, 2009, Rotin and Kumar, 2009)

Ube3a

Ubiquitin protein ligase E3A

dube3a, Angelman syndrome, As, Drosophila Angelman syndrome, das

(FlyBase, 2017-, Du et al., 2011, Marin, 2010)

Ufd4

Ubiquitin fusion-degradation 4-like

(FlyBase, 2017-, Du et al., 2011)

INHIBITOR OF APOPTOSIS UBIQUITIN LIGASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Diap1

Death-associated inhibitor of apoptosis 1

th, thread, DIAP-1, Drosophila inhibitor of apoptosis 1, DIAP

(FlyBase, 2017-, Darding and Meier, 2012, Vandenabeele and Bertrand, 2012, Du et al., 2011, Ying et al., 2011)

Diap2

Death-associated inhibitor of apoptosis 2

Iap2, DIAP-2, DIAP, DIHA, IAP-like protein

(FlyBase, 2017-, Darding and Meier, 2012, Vandenabeele and Bertrand, 2012, Du et al., 2011, Ying et al., 2011)

KCMF1 UBIQUITIN LIGASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG3526

EG:BACR43E12.4

(FlyBase, 2017-)

CG15286

BG:DS01068.11

(FlyBase, 2017-)

CG31642

(FlyBase, 2017-)

CG31835

BG:DS00810.1

(FlyBase, 2017-)

CG42585

(FlyBase, 2017-)

Kcmf1

Potassium channel modulatory factor 1

(FlyBase, 2017-)

RING-BETWEEN-RING UBIQUITIN LIGASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

ari-1

ariadne 1

ari, ariadne, HL-V

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Eisenhaber et al., 2007)

ari-2

ariadne 2

ari2, l(2)07768

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Eisenhaber et al., 2007)

CG12362

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Eisenhaber et al., 2007)

CG33144

lincRNA.281

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Eisenhaber et al., 2007)

LUBEL

Linear Ubiquitin E3 ligase

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Eisenhaber et al., 2007)

park

parkin

dParkin, D-parkin, dpk

(FlyBase, 2017-, Eisenhaber et al., 2007)

ROC UBIQUITIN LIGASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Roc1a

Regulator of cullins 1a

Rbx1, EG:115C2.11, dRbx1, ROC1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Jin and Harper, 2002)

Roc1b

Regulator of cullins 1b

ROC2

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Jin and Harper, 2002)

Roc2

Regulator of cullins 2

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Jin and Harper, 2002)

TRIM UBIQUITIN LIGASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

bon

bonus

(FlyBase, 2017-, Wisotzkey et al., 2014, Du et al., 2011, Ying et al., 2011, Sardiello et al., 2008)

CG8419

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Sardiello et al., 2008)

mei-P26

meiotic P26

BcDNA:GH10646

(FlyBase, 2017-, Wisotzkey et al., 2014, Du et al., 2011, Ying et al., 2011, Sardiello et al., 2008)

thin

abba, TRIM32, l(2)tn

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Sardiello et al., 2008)

Trim9

Tripartite motif containing 9

dTrim9, asap

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Sardiello et al., 2008)

U-BOX UBIQUITIN LIGASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG2218

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Marin, 2010)

CG6179

(FlyBase, 2017-, Ying et al., 2011)

CG7747

(FlyBase, 2017-, Ying et al., 2011, Marin, 2010)

Prp19

Pre-RNA processing factor 19

l(2)07838, Gbp

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Marin, 2010)

STUB1

STIP1 homology and U-box containing protein 1

CHIP, dCHIP

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Marin, 2010)

Ube4A

Ubiquitination factor E4A

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Marin, 2010)

Ube4B

Ubiquitination factor E4B

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011, Marin, 2010)

UNCLASSIFIED E3 UBIQUITIN LIGASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

(FlyBase, 2017-)

Inhibitor-3

(FlyBase, 2017-)

Neurl4

Neuralized E3 ubiquitin protein ligase 4

(FlyBase, 2017-)

poe

purity of essence

push, pushover, Calo, Ubr4, Calossin

(FlyBase, 2017-)

Rabex-5

Rabaptin-5-associated exchange factor for Rab5

(Washington et al., 2020)

UNCLASSIFIED RING DOMAIN UBIQUITIN LIGASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Bre1

l(3)01640, dBre1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Cbl

Cbl proto-oncogene

D-cbl, dCbl, D-cblL, D-cblS, Dv-cbl

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG1317

(FlyBase, 2017-, Ying et al., 2011)

CG2617

38E.2

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG2681

EG:100G10.2

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG2991

(FlyBase, 2017-, Ying et al., 2011)

CG4080

(FlyBase, 2017-, Ying et al., 2011)

CG4325

EG:22E5.12

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG5334

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG5347

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG5555

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG6923

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG7376

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG7694

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG8141

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG9014

BG:DS08249.3

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG10761

(FlyBase, 2017-, Ying et al., 2011)

CG10916

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG11360

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG11414

ZNF598

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG12099

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG12477

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG13344

anon-EST:GressD1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG13442

(FlyBase, 2017-, Ying et al., 2011)

CG13481

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG13605

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG14983

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG15141

(FlyBase, 2017-)

CG15814

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG16781

(FlyBase, 2017-, Ying et al., 2011)

CG17019

dRNF34

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG17329

BG:DS02740.5, DS02740.5

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG17717

(FlyBase, 2017-, Ying et al., 2011)

CG17721

(FlyBase, 2017-)

CG17991

(FlyBase, 2017-, Ying et al., 2011)

CG31807

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG32369

(FlyBase, 2017-)

CG32847

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG33552

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG34308

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

CG34375

(FlyBase, 2017-)

Cnot4

CCR4-NOT transcription complex subunit 4

NOT4, dNOT4

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

detr

detour

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

dgrn

degringolade

STUbL

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

dnr1

defense repressor 1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

dor

deep orange

Vps18, EG:171E4.1, Dof, l(1)7

(FlyBase, 2017-)

deltex

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

elfless

(FlyBase, 2017-)

elgi

early girl

Nrdp1, dNrdp1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Fancl

(FlyBase, 2017-)

Hakai

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

hiw

highwire

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Iru

Iruka

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Kaz

Katazuke

(Zavortink et al., 2020, FlyBase, 2017-)

Kpc1

Kip1 ubiquitination-promoting complex subunit 1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

lmgA

lemming A

lmg, lemming, l(2)03424, APC11

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Ltn1

Listerin E3 ubiquitin protein ligase 1

l(3)76BDr

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

March5

(FlyBase, 2017-, Ying et al., 2011)

mdlc

midlife crisis

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

mib1

mind bomb 1

D-mib, l(3)72CDa, Dmib, mib, Mindbomb

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

mib2

mind bomb 2

l(2)37Be, Be, D-mibl

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Mkrn1

Makorin 1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Mrgn1

Mahogunin ring finger 1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

msl-2

male-specific lethal 2

MSL2, MSL, kmA

(FlyBase, 2017-, Du et al., 2011)

Mul1

Mitochondrial E3 ubiquitin protein ligase 1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

mura

murashka

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

mus302

mutagen-sensitive 302

mus(3)302

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

neur

neuralized

neu, Neuralised

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

nopo

no poles

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Nse1

Non-SMC element 1

(FlyBase, 2017-, Ying et al., 2011)

Pex2

Peroxin 2

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Pex10

Peroxin 10

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Pex12

Peroxin 12

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Pits

Protein interacting with Ttk69 and Sin3A

(FlyBase, 2017-)

Pli

Pellino

(FlyBase, 2017-, Ji et al., 2014)

POSH

Plenty of SH3s

DPOSH, l(2)k15815

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Rchy1

Ring finger and CHY zinc finger domain containing 1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Rnf11

Ring finger protein 11

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Rnf146

Ring finger protein 146

Iduna

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

RNF220

ring finger protein 220

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

roq

roquin

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Sce

Sex combs extra

dRING, dRING1, Ring, Sex comb extra, RING1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

sina

seven in absentia

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

sinah

sina homologue

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

sip3

septin interacting protein 3

Hrd1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

snama

something that sticks like glue

l(2)rQ313, BcDNA:LD21643, mini-me, mnm

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

snky

sneaky

ms(3)ry4, ms(3)snky, ms(3)4, ms(3)sneaky

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

sordd1

suppression of retinal degeneration disease 1 upon overexpression 1

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

sordd2

suppression of retinal degeneration disease 1 upon overexpression 2

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Sou

Souji

(Zavortink et al., 2020, FlyBase, 2017-)

stc

shuttle craft

l(2)35Cb, l(2)br33, br33, BG:DS04929.4

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

tey

teyrha-meyrha

(FlyBase, 2017-)

Topors

Topoisomerase I-interacting protein

dTopors, nuclear blebber, nbl

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Traf6

TNF-receptor-associated factor 6

dTRAF2, Traf2, dTraf6, EP325

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Trc8

TRC8 ring finger protein

DTrc8

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Ubr1

Ubr1 ubiquitin ligase

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Ubr3

Ubr3 ubiquitin ligase

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

Vps11

Vacuolar protein sorting 11

(FlyBase, 2017-, Du et al., 2011, Ying et al., 2011)

External Data

Equivalent Group(s)

Other resource(s)

Synonyms and Secondary IDs

Synonym(s)

UBT

UBIQUITIN TRANSFERASES

Secondary FlyBase ID(s)

References (21)

Report Sections

Open Close