FB2024_04 , released June 25, 2024
Gene Group: NON-RECEPTOR TKL KINASES
Open Close
General Information
Name
NON-RECEPTOR TKL KINASES
Species
D. melanogaster
Symbol
TKL-NR
FlyBase ID
FBgg0001090
Date last reviewed
2022-11-01
Number of members
11
Description
Description
Non-receptor tyrosine kinase-like (TKL) kinases are a diverse group of intracellular serine-threonine protein kinases with sequence similarity to tyrosine kinases (TK) but lacking TK-specific motifs.
Notes on Group

Ilk is predicted to be a pseudokinase based on sequence analysis (FBrf0209106) and is therefore omitted from this group.

In the MAPK (ERK) cascade, ksr acts as a MAP-kinase scaffold, facilitating the phosphorylation and activation of Dsor1 by Raf (FBrf0144882). The mouse ortholog, Ksr1, shows some protein kinase activity in vitro, although the physiological relevance of this activity is unknown (PMID:21441104).

Source Material
The NON-RECEPTOR TKL KINASES Gene Group has been compiled using the following publication(s): Sopko et al., 2014, Manning et al., 2002, Manning et al., 2002, and Morrison et al., 2000 .
Key Gene Ontology (GO) terms
Molecular Function
protein serine/threonine kinase activity
Biological Process
protein phosphorylation
Cellular Component
Enzymatic activity
Enzyme name (EC)
non-specific serine/threonine protein kinase (2.7.11.1)
Related Gene Groups
Parent group(s)
TYROSINE KINASE-LIKE KINASES
Members (11)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
cdi
center divider
l(3)07013, 91F, B9.3, 91F gene
(Sopko et al., 2014, Manning et al., 2002, Manning et al., 2002, Morrison et al., 2000)
ksr
kinase suppressor of ras
l(3)j5E2, SR3-1
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
LIMK1
LIM domain kinase 1
LIMK, agn, Dlimk, agnostic, LIM kinase
(Sopko et al., 2014, Manning et al., 2002, Manning et al., 2002, Morrison et al., 2000)
Lrrk
Leucine-rich repeat kinase
LRRK2, dLRRK, dLRRK2
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
pll
pelle
(Sopko et al., 2014, Manning et al., 2002, Manning et al., 2002, Morrison et al., 2000)
Raf
Raf oncogene
D-raf, Draf, phl, pole hole, l(1)ph
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
slpr
slipper
MLK2, dMLK, MLK, JNKKK
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Tak1
TGF-β activated kinase 1
dTAK1, dTAK, TAK, dTAK-1, DmTak1
(Sopko et al., 2014, Manning et al., 2002, Manning et al., 2002, Morrison et al., 2000)
Takl1
Tak1-like 1
(Sopko et al., 2014, Manning et al., 2002, Manning et al., 2002, Morrison et al., 2000)
Takl2
Tak1-like 2
(Sopko et al., 2014, Manning et al., 2002, Manning et al., 2002, Morrison et al., 2000)
wnd
wallenda
DLK
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
TKL-NR
NON-RECEPTOR TLK KINASES
NON-RECEPTOR TKL KINASES
Secondary FlyBase ID(s)
References (5)