FB2024_02 , released April 23, 2024
Gene Group: PEPTIDASE FAMILY S1A
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General Information
Name
PEPTIDASE FAMILY S1A
Species
D. melanogaster
Symbol
S1A
FlyBase ID
FBgg0001075
Date last reviewed
2019-03-07
Number of members
258
Description
Description
The S1A family of peptidases comprises serine proteases and the non-catalytic serine protease homologs belonging to MEROPS peptidase family S1, subfamily A. They play essential roles in a wide range of insect physiological processes including digestion, defense and development. (Adapted from FBrf0240739.)
Notes on Group

The membership of and classifications within the PEPTIDASE FAMILY S1A group generally follows the analysis of Cao and Jiang 2018 (FBrf0240739), which was improved and updated compared to previous analyses (Ross et al. 2003 (FBrf0155784), Shah et al. 2008 (FBrf0202030), Veillard et al 2016 (FBrf0230906), MEROPS database (FBrf0239469)).

Source Material
The PEPTIDASE FAMILY S1A Gene Group has been compiled using the following publication(s): Jiang, 2019.3.1, Cao and Jiang, 2018, Veillard et al., 2016, Shah et al., 2008, Ross et al., 2003, and Rawlings and Barrett, 1996- .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Cellular Component
Related Gene Groups
Parent group(s)
PEPTIDASE FAMILY S1
Component group(s)
S1A NON-PEPTIDASE HOMOLOGS
S1A SERINE PROTEASES
Members (258)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
S1A NON-PEPTIDASE HOMOLOGS
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
aqrs
aquarius
(Cao and Jiang, 2018)
CG1632
SPH198
(Cao and Jiang, 2018)
CG3088
SPH188
(Cao and Jiang, 2018)
CG3117
(Cao and Jiang, 2018)
CG3505
(Cao and Jiang, 2018)
CG4259
SPH173
(Cao and Jiang, 2018)
CG4271
SPH164
(Cao and Jiang, 2018)
CG4477
(Cao and Jiang, 2018)
CG4650
SPH197
(Cao and Jiang, 2018)
CG4653
SPH179
(Cao and Jiang, 2018)
CG4793
BG:DS07486.3
(Cao and Jiang, 2018)
CG4998
(Cao and Jiang, 2018)
CG6067
(Cao and Jiang, 2018)
CG8586
(Cao and Jiang, 2018)
CG8738
(Cao and Jiang, 2018)
CG9377
(Cao and Jiang, 2018)
CG9672
SPH161
(Cao and Jiang, 2018)
CG9673
SPH81
(Cao and Jiang, 2018)
CG9897
SPH195
(Cao and Jiang, 2018)
CG9997
(Cao and Jiang, 2018)
CG13318
(Cao and Jiang, 2018)
CG13527
SPH182
(Cao and Jiang, 2018)
CG14088
SPH199
(Cao and Jiang, 2018)
CG14990
SPH97
(Cao and Jiang, 2018)
CG15046
(Jiang, 2019.3.1)
CG15873
SPH184
(Cao and Jiang, 2018)
CG17242
SPH187, anon-SAGE:Wang-110
(Cao and Jiang, 2018)
CG17572
(Cao and Jiang, 2018)
CG18223
SPH200
(Cao and Jiang, 2018)
CG18420
BG:DS06874.6, SPH111
(Cao and Jiang, 2018)
CG18477
BG:DS07108.1
(Cao and Jiang, 2018)
CG18478
BG:DS07108.5, DS07108.5, SPH157
(Cao and Jiang, 2018)
CG18557
(Cao and Jiang, 2018)
CG18563
(Cao and Jiang, 2018)
CG30323
SPH206
(Cao and Jiang, 2018)
CG31199
(Cao and Jiang, 2018)
CG31200
(Cao and Jiang, 2018)
CG31205
(Cao and Jiang, 2018)
CG31266
(Cao and Jiang, 2018)
CG31267
(Cao and Jiang, 2018)
CG31326
SPH144
(Cao and Jiang, 2018)
CG31780
(Cao and Jiang, 2018)
CG31827
(Cao and Jiang, 2018)
CG32833
(Cao and Jiang, 2018)
CG32834
(Cao and Jiang, 2018)
CG33127
(Cao and Jiang, 2018)
CG33225
(Cao and Jiang, 2018)
CG33460
(Cao and Jiang, 2018)
CG33465
(Cao and Jiang, 2018)
CG34129
(Cao and Jiang, 2018)
CG34130
(Cao and Jiang, 2018)
CG34171
(Cao and Jiang, 2018)
CG34295
(Cao and Jiang, 2018)
CG34436
(Cao and Jiang, 2018)
CG34437
(Cao and Jiang, 2018)
CG42694
(Cao and Jiang, 2018)
CG43124
(Cao and Jiang, 2018)
CG43125
(Cao and Jiang, 2018)
intr
intrepid
SPH202
(Cao and Jiang, 2018)
κTry
κTry
SPH109
(Cao and Jiang, 2018)
mas
masquerade
(Cao and Jiang, 2018)
scaf
scarface
(Cao and Jiang, 2018)
Sph35
Serine protease homolog 35
cSPH35
(Cao and Jiang, 2018)
SPH93
Serine protease homolog 93
(Cao and Jiang, 2018)
Sph242
Serine protease homolog 242
cSPH242
(Cao and Jiang, 2018)
sphe
spheroide
SPH114
(Cao and Jiang, 2018)
sphinx1
sphinx1
SPH194
(Cao and Jiang, 2018)
sphinx2
sphinx2
SPH194
(Cao and Jiang, 2018)
S1A SERINE PROTEASES - CHYMOTRYPSIN-LIKE
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG3916
SP154
(Cao and Jiang, 2018)
CG4053
SP185
(Cao and Jiang, 2018)
CG4815
SP189
(Cao and Jiang, 2018)
CG5246
SP96
(Cao and Jiang, 2018)
CG5255
SP141
(Cao and Jiang, 2018)
CG5909
(Cao and Jiang, 2018)
CG6462
SP127
(Cao and Jiang, 2018)
CG6592
lincRNA.S4213, SP105
(Cao and Jiang, 2018)
CG7142
SP132
(Cao and Jiang, 2018)
CG7542
SP71
(Cao and Jiang, 2018)
CG8329
SP170
(Cao and Jiang, 2018)
CG9649
SP55
(Cao and Jiang, 2018)
CG10041
SP178
(Cao and Jiang, 2018)
CG10469
SP123
(Cao and Jiang, 2018)
CG10472
SP78
(Cao and Jiang, 2018)
CG10477
SP51
(Cao and Jiang, 2018)
CG11664
EG:BACR7A4.3, SP193
(Cao and Jiang, 2018)
CG11911
SP103
(Cao and Jiang, 2018)
CG11912
SP140
(Cao and Jiang, 2018)
CG12256
SP133
(Cao and Jiang, 2018)
CG12951
SP87
(Cao and Jiang, 2018)
CG14227
(Cao and Jiang, 2018)
CG14892
SP175
(Cao and Jiang, 2018)
CG16749
SP91
(Cao and Jiang, 2018)
CG17234
SP113
(Cao and Jiang, 2018)
CG17404
SP149
(Cao and Jiang, 2018)
CG17475
SP131
(Cao and Jiang, 2018)
CG18179
SP152
(Cao and Jiang, 2018)
CG18636
(Cao and Jiang, 2018)
CG30098
(Cao and Jiang, 2018)
CG30283
SP37
(Cao and Jiang, 2018)
CG30287
(Cao and Jiang, 2018)
CG31220
(Cao and Jiang, 2018)
CG31265
(Cao and Jiang, 2018)
CG31269
(Cao and Jiang, 2018)
CG32523
SP50
(Cao and Jiang, 2018)
CG32808
EG:80H7.1
(Cao and Jiang, 2018)
CG33226
(Cao and Jiang, 2018)
CG33459
(Cao and Jiang, 2018)
CG34458
SP118
(Cao and Jiang, 2018)
CG43335
(Cao and Jiang, 2018)
CG43336
(Cao and Jiang, 2018)
gd
gastrulation-defective
fs(1)M18, fs(1)gd, fs(1)573, SP186
(Cao and Jiang, 2018)
Jon25Biii
Jonah 25Biii
SP177, Jon25B
(Cao and Jiang, 2018)
Jon44E
Jonah 44E
SP100
(Cao and Jiang, 2018)
Jon65Ai
Jonah 65Ai
Jon65A, SP145
(Cao and Jiang, 2018)
Jon65Aii
Jonah 65Aii
Jon65A, SP153
(Cao and Jiang, 2018)
Jon65Aiv
Jonah 65Aiv
Jon65A, BEST:GH23808, SP117
(Cao and Jiang, 2018)
Jon66Cii
Jonah 66Cii
Jonah 66C, Jon66C, SP165
(Cao and Jiang, 2018)
Jon74E
Jonah 74E
SP85
(Cao and Jiang, 2018)
Jon99Cii
Jonah 99Cii
Ser99Da, Jon99C, Jon99Cβ, Ser1, SP122
(Cao and Jiang, 2018)
Jon99Ciii
Jonah 99Ciii
Ser99Db, Ser2, Jon99Cβ, Jon99C, Serine protease 5
(Cao and Jiang, 2018)
Jon99Fi
Jonah 99Fi
Jon99F
(Cao and Jiang, 2018)
Jon99Fii
Jonah 99Fii
Jon99F, SP135
(Cao and Jiang, 2018)
modSP
modular serine protease
W, X, Ser89E, SP53
(Cao and Jiang, 2018)
Phae1
Phaedra 1
SP134
(Cao and Jiang, 2018)
Phae2
Phaedra 2
SP147
(Cao and Jiang, 2018)
Send1
Spermathecal endopeptidase 1
SP163
(Cao and Jiang, 2018)
Send2
Spermathecal endopeptidase 2
BG:DS01068.10
(Cao and Jiang, 2018)
Sp212
Serine-peptidase 212
(Cao and Jiang, 2018)
yip7
yippee interacting protein 7
Machete, SP116
(Cao and Jiang, 2018)
S1A SERINE PROTEASES - ELASTASE-LIKE
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG1304
SP46
(Cao and Jiang, 2018)
CG8952
SP52
(Cao and Jiang, 2018)
CG9631
SP60, BcDNA:GH08420
(Cao and Jiang, 2018)
CG9676
SP99
(Cao and Jiang, 2018)
CG17477
(Cao and Jiang, 2018)
CG18180
SP151
(Cao and Jiang, 2018)
CG33458
(Cao and Jiang, 2018)
CG33461
(Cao and Jiang, 2018)
CG33462
(Cao and Jiang, 2018)
Jon25Bi
Jonah 25Bi
Ser4, Jon25B, SP137
(Cao and Jiang, 2018)
Jon25Bii
Jonah 25Bii
SP112, Jon25B
(Cao and Jiang, 2018)
Jon65Aiii
Jonah 65Aiii
Jon65A, SP98
(Cao and Jiang, 2018)
Jon66Ci
Jonah 66Ci
SP171, Jon66C, Jonah 66C
(Cao and Jiang, 2018)
Jon99Ci
Jonah 99Ci
Ser99Dc, Jon99C, Jon99Cβi, SP150, SER3
(Cao and Jiang, 2018)
Ser6
Serine protease 6
SP47
(Cao and Jiang, 2018)
S1A SERINE PROTEASES - TRYPSIN-LIKE
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
αTry
αTrypsin
alpha, SP102, Try
(Cao and Jiang, 2018)
βTry
βTrypsin
SP119, Try
(Cao and Jiang, 2018)
CG1299
SP18
(Cao and Jiang, 2018)
CG1773
SP74
(Cao and Jiang, 2018)
CG3355
SP21
(Cao and Jiang, 2018)
CG3650
SP159
(Cao and Jiang, 2018)
CG3700
(Cao and Jiang, 2018)
CG3795
EG:9D2.4, SP160
(Cao and Jiang, 2018)
CG4613
SP40
(Cao and Jiang, 2018)
CG4914
SP39
(Cao and Jiang, 2018)
CG4927
(Cao and Jiang, 2018)
CG6041
SP86
(Cao and Jiang, 2018)
CG6048
SP108
(Cao and Jiang, 2018)
CG6865
SP63
(Cao and Jiang, 2018)
CG7432
(Cao and Jiang, 2018)
CG7829
SP136
(Cao and Jiang, 2018)
CG8170
(Cao and Jiang, 2018)
CG8172
(Cao and Jiang, 2018)
CG8299
SP65
(Cao and Jiang, 2018)
CG8870
(Cao and Jiang, 2018)
CG9294
SP20
(Cao and Jiang, 2018)
CG9372
(Cao and Jiang, 2018)
CG9733
pro-phenoloxidase AE, SP10, proAE
(Cao and Jiang, 2018)
CG9737
(Cao and Jiang, 2018)
CG10232
(Cao and Jiang, 2018)
CG10405
SP155
(Cao and Jiang, 2018)
CG10587
SP167
(Cao and Jiang, 2018)
CG10663
SP30
(Cao and Jiang, 2018)
CG10764
SP77
(Cao and Jiang, 2018)
CG11037
SP191
(Cao and Jiang, 2018)
CG11192
SP82
(Cao and Jiang, 2018)
CG11313
(Cao and Jiang, 2018)
CG11529
SP84
(Cao and Jiang, 2018)
CG11668
(Cao and Jiang, 2018)
CG11670
SP27
(Cao and Jiang, 2018)
CG11836
SP23
(Cao and Jiang, 2018)
CG11841
SP45
(Cao and Jiang, 2018)
CG11842
SP68
(Cao and Jiang, 2018)
CG11843
SP43
(Cao and Jiang, 2018)
CG12133
SP15
(Cao and Jiang, 2018)
CG13430
SP70
(Cao and Jiang, 2018)
CG13744
(Cao and Jiang, 2018)
CG14642
SP29
(Cao and Jiang, 2018)
CG14760
SP120
(Cao and Jiang, 2018)
CG14780
SP95, EG:80H7.3
(Cao and Jiang, 2018)
CG16710
(Cao and Jiang, 2018)
CG16998
SP104
(Cao and Jiang, 2018)
CG17239
SP138
(Cao and Jiang, 2018)
CG17571
38C.22, anon-38C.22, SP83
(Cao and Jiang, 2018)
CG18735
SP22
(Cao and Jiang, 2018)
CG18754
(Cao and Jiang, 2018)
CG30002
(Cao and Jiang, 2018)
CG30025
(Cao and Jiang, 2018)
CG30031
(Cao and Jiang, 2018)
CG30082
(Cao and Jiang, 2018)
CG30083
(Cao and Jiang, 2018)
CG30087
(Cao and Jiang, 2018)
CG30088
(Cao and Jiang, 2018)
CG30091
SP49
(Cao and Jiang, 2018)
CG30187
(Cao and Jiang, 2018)
CG30286
(Cao and Jiang, 2018)
CG30288
(Cao and Jiang, 2018)
CG30289
(Cao and Jiang, 2018)
CG30371
(Cao and Jiang, 2018)
CG30375
(Cao and Jiang, 2018)
CG30414
SP62
(Cao and Jiang, 2018)
CG31219
(Cao and Jiang, 2018)
CG31681
(Cao and Jiang, 2018)
CG31954
SP107
(Cao and Jiang, 2018)
CG32260
(Cao and Jiang, 2018)
CG32269
(Cao and Jiang, 2018)
CG32270
(Cao and Jiang, 2018)
CG32271
(Cao and Jiang, 2018)
CG32277
(Cao and Jiang, 2018)
CG32374
(Cao and Jiang, 2018)
CG32376
(Cao and Jiang, 2018)
CG32755
(Cao and Jiang, 2018)
CG33159
(Cao and Jiang, 2018)
CG33160
(Cao and Jiang, 2018)
CG34290
(Cao and Jiang, 2018)
CG34409
(Cao and Jiang, 2018)
CG43110
MB7.chr2R.pasa.4777
(Cao and Jiang, 2018)
CG43742
(Cao and Jiang, 2018)
Corin
Corin
SP75
(Cao and Jiang, 2018)
δTry
δTrypsin
(Cao and Jiang, 2018)
ea
easter
(Cao and Jiang, 2018)
εTry
εTrypsin
epsilonTrypsin, SP88, Try
(Cao and Jiang, 2018)
Erasp
Endoplasmic reticulum stress-associated serine protease
(Cao and Jiang, 2018)
ηTry
ηTrypsin
SP57
(Cao and Jiang, 2018)
flz
filzig
lint, lumens interrupted
(Cao and Jiang, 2018)
γTry
γTrypsin
(Cao and Jiang, 2018)
grass
Gram-positive Specific Serine protease
c-SP1
(Cao and Jiang, 2018)
Hayan
Hayan
(Cao and Jiang, 2018)
ιTry
ιTrypsin
SP129
(Cao and Jiang, 2018)
l(2)k05911
lethal (2) k05911
(Cao and Jiang, 2018)
λTry
λTry
SP76
(Cao and Jiang, 2018)
MP1
Melanization Protease 1
BEST:GH02921
(Cao and Jiang, 2018)
ndl
nudel
SP89
(Cao and Jiang, 2018)
Np
Notopleural
(Cao and Jiang, 2018)
psh
persephone
(Cao and Jiang, 2018)
Sb
Stubble
sbd, Sb-sbd, stubbloid, Stubble-stubbloid
(Cao and Jiang, 2018)
Sems
Seminase
SP168
(Cao and Jiang, 2018)
Ser7
Ser7
SP#2
(Cao and Jiang, 2018)
Ser8
Ser8
SP90, SP#3
(Cao and Jiang, 2018)
Ser12
Serine protease 12
SP92
(Cao and Jiang, 2018)
snk
snake
(Cao and Jiang, 2018)
Sp7
Serine protease 7
MP2, PAE1, Melanization Protease 2
(Cao and Jiang, 2018)
SPE
Spatzle-Processing Enzyme
c-SP4
(Cao and Jiang, 2018)
spirit
Serine Protease Immune Response Integrator
c-SP33
(Cao and Jiang, 2018)
teq
Tequila
graal, SP72
(Cao and Jiang, 2018)
θTry
θTrypsin
SP139
(Cao and Jiang, 2018)
tpr
tracheal-prostasin
SP17
(Cao and Jiang, 2018)
Try29F
Trypsin 29F
SP106
(Cao and Jiang, 2018)
ζTry
ζTrypsin
SP110
(Cao and Jiang, 2018)
External Data
Equivalent Group(s)
Other resource(s)

[MEROPS Peptidase Database: Family S1](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=S1)

Synonyms and Secondary IDs
Synonym(s)
S1A
PEPTIDASE FAMILY S1A
SERINE PROTEASE-RELATED PROTEINS
SPR
Secondary FlyBase ID(s)
References (7)