FB2024_02 , released April 23, 2024
Gene Group - Pathway: Notch Signaling Pathway
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General Information
Name
Notch Signaling Pathway
Species
D. melanogaster
Symbol
NTCH
FlyBase ID
FBgg0001068
Date last reviewed
2024-03-08
Number of members
86
Description
Description
The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Notch cell-cell signaling is important in many cell fate decisions during development and in tissue homeostasis. (Adapted from FBrf0225731 and FBrf0192604).
Notes and selected reviews

Selected publications for background information: Introduction to notch signaling (FBrf0225731), Notch signalling: a simple pathway becomes complex (FBrf0192604) and Tools and methods for studying Notch signaling in Drosophila melanogaster (FBrf0225258).

Note: Pathway Pages in FlyBase are under development. The pathway gene tables display genes that have been experimentally shown to act within the pathway or modify pathway activity. We welcome any feedback to help improve the usefulness and accuracy of these gene lists.

Biological Process Gene Ontology (GO) term(s)
Related Gene Groups
Component group(s)
Negative Regulators of Notch Signaling Pathway
Notch Signaling Pathway Core Components
Positive Regulators of Notch Signaling Pathway
Physical Interaction Network
Members (86)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Negative Regulators of Notch Signaling Pathway
Notch Signaling Pathway Core Components
Positive Regulators of Notch Signaling Pathway
External Data
Other resource(s)

[Illustration - Notch signaling (The Interactive Fly)](http://www.sdbonline.org/sites/fly/pathway/aapathway2.htm#Not)

[Wikipathways - Notch Signaling Pathway (Drosophila melanogaster)](https://www.wikipathways.org/index.php/ Pathway:WP208 )

[Animation - The Notch signaling pathway (Wolpert, Tickle & Martinez Arias:Principles of Development International 5e)](https://www.youtube.com/watch?v=axkDX0XZyN0)

[Reactome Pathway - Signaling by Notch (computed)](https://reactome.org/PathwayBrowser/#/R-DME-157118&PATH=R-DME-162582)

[KEGG pathway - Notch signaling pathway - Drosophila melanogaster](https://www.genome.jp/kegg-bin/show_pathway?dme04330)

Synonyms and Secondary IDs
Synonym(s)
NTCH
Notch Signaling Pathway
Secondary FlyBase ID(s)
References (172)