FB2024_02 , released April 23, 2024
Gene Group - Pathway: FGFR Signaling Pathway
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General Information
Name
FGFR Signaling Pathway
Species
D. melanogaster
Symbol
FGFR
FlyBase ID
FBgg0000967
Date last reviewed
2021-07-06
Number of members
34
Description
Description
Fibroblast Growth Factor Receptor (FGFR) signaling pathway is initiated by the binding of secreted FGFs - bnl or ths/pyr to receptor tyrosine kinases btl or htl, respectively, to initiate signaling primarily via the canonical Ras/Raf/MAP kinase (ERK) cascade. FGFR signaling is important in several morphogenic events in Drosophila, notably during mesoderm and tracheal development. (Adapted from FBrf0221038).
Notes and selected reviews

Note: Pathway Pages in FlyBase are under development. The pathway gene tables display genes that have been experimentally shown to act within the pathway or modify pathway activity. We welcome any feedback to help improve the usefulness and accuracy of these gene lists.

Selected publications for background information: Functions and Mechanisms of Fibroblast Growth Factor (FGF) Signalling in Drosophila melanogaster (FBrf0221038), FGF signaling in flies and worms: more and more relevant to vertebrate biology (FBrf0187375), Receptor tyrosine kinases in Drosophila development (FBrf0221727).

Biological Process Gene Ontology (GO) term(s)
Related Gene Groups
Component group(s)
FGFR Signaling Pathway Core Components
Negative Regulators of FGFR Signaling Pathway
Positive Regulators of FGFR Signaling Pathway
Physical Interaction Network
Members (34)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
FGFR Signaling Pathway Core Components
Negative Regulators of FGFR Signaling Pathway
Positive Regulators of FGFR Signaling Pathway
External Data
Other resource(s)

[Illustration - Schematic model of the canonical FGF signalling cascade in Drosophila. (The Interactive Fly)](http://www.sdbonline.org/sites/fly/pathway/aapathway.htm#Fgf)

Synonyms and Secondary IDs
Synonym(s)
FGFR
FGFR Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Secondary FlyBase ID(s)
References (49)