FB2024_02 , released April 23, 2024
Gene Group - Pathway: EGFR Signaling Pathway
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General Information
Name
EGFR Signaling Pathway
Species
D. melanogaster
Symbol
EGFR-RTK
FlyBase ID
FBgg0000958
Date last reviewed
2023-02-08
Number of members
80
Description
Description
Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand - the transforming growth factor-α-like ligands:spi, Krn, grk or the neuregulin-like ligand vn, to the receptor tyrosine kinase Egfr. The pathway can be regulated by the maturation and secretion of TGF-α-like ligands. The EGFR signaling pathway acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
Notes and selected reviews

Selected publications for background information: Regulating the dynamics of EGF receptor signaling in space and time (FBrf0190321), Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer (FBrf0234746), Signaling by the Drosophila epidermal growth factor receptor pathway during development (FBrf0158927), Receptor tyrosine kinases in Drosophila development (FBrf0221727).

Note: Pathway Pages in FlyBase are under development. The pathway gene tables display genes that have been experimentally shown to act within the pathway or modify pathway activity. We welcome any feedback to help improve the usefulness and accuracy of these gene lists.

Biological Process Gene Ontology (GO) term(s)
Related Gene Groups
Component group(s)
EGFR Ligand Production
EGFR Signaling Pathway Core Components
Negative Regulators of EGFR Signaling Pathway
Positive Regulators of EGFR Signaling Pathway
Physical Interaction Network
Members (80)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
EGFR Ligand Production
EGFR Signaling Pathway Core Components
Negative Regulators of EGFR Signaling Pathway
Positive Regulators of EGFR Signaling Pathway
External Data
Other resource(s)

[Illustration - Feedback regulation of EGFR signalling in the Drosophila eye (The Interactive Fly)](http://www.sdbonline.org/sites/fly/pathway/aapathway.htm#Egr1)

[Gene List - Genes of the ras pathway and Egfr receptor-ligand complex (The Interactive Fly)](http://www.sdbonline.org/sites/fly/aignfam/egfr&ras.htm)

[KEGG pathway - MAPK signaling pathway-fly](https://www.genome.jp/kegg-bin/show_pathway?ko04013)

[Illustration - Model for the effect of Myopic on EGFR endocytosis in Drosophila (The Interactive Fly)](http://www.sdbonline.org/sites/fly/pathway/aapathway.htm#Egr2)

Synonyms and Secondary IDs
Synonym(s)
EGFR-RTK
ErbB Signaling Pathway
EGF receptor pathway
EGFR Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Secondary FlyBase ID(s)
References (139)