Gene Group - Pathway: Sevenless Signaling Pathway

General Information

Name

Sevenless Signaling Pathway

Species

D. melanogaster

Symbol

SEVL

FlyBase ID

FBgg0000941

Date last reviewed

2020-01-16

Number of members

Description

The specification of the R7 photoreceptor cell in each ommatidium of the developing Drosophila eye is dependent on activation of Sevenless receptor tyrosine kinase (sev), which acts via the canonical Ras/Raf/MAP kinase cascade to promote the expression of lz and pros. sev, expressed in presumptive R7 cells, is activated by binding to Bride of Sevenless (boss), a seven-transmembrane protein expressed in R8 cells. (Adapted from FBrf0127283 and FBrf0221727).

Notes and selected reviews

Selected publications for background information: Signal transduction and the fate of the R7 photoreceptor in Drosophila (FBrf0055173), The Sevenless signaling pathway: variations of a common theme (FBrf0127283), The fly eye: Through the looking glass (FBrf0237528), The little R cell that could (FBrf0180351), Parsimony and complexity: Cell fate assignment in the developing Drosophila eye (FBrf0236340), Receptor tyrosine kinases in Drosophila development (FBrf0221727).

Note: Pathway Pages in FlyBase are under development. The pathway gene tables display genes that have been experimentally shown to act within the pathway or modify pathway activity. We welcome any feedback to help improve the usefulness and accuracy of these gene lists.

Biological Process Gene Ontology (GO) term(s)

Related Gene Groups

Component group(s)

Negative Regulators of Sevenless Signaling Pathway

Positive Regulators of Sevenless Signaling Pathway

Sevenless Signaling Pathway Core Components

Physical Interaction Network

Members (30)

For all members: