FB2024_02 , released April 23, 2024
Gene Group: TETRASPANINS
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General Information
Name
TETRASPANINS
Species
D. melanogaster
Symbol
TSP
FlyBase ID
FBgg0000532
Date last reviewed
2016-06-29
Number of members
38
Description
Description
Tetraspanins (TSP) have four transmembrane domains and two extracellular loops containing specific short motifs, including highly conserved cysteine residues. TSPs are thought to function as scaffolds that bring multiple proteins - including other TSPs, membrane-associated proteins, extracellular and cytosolic proteins - into single membrane region. These regions are called tetraspanin-enriched microdomains. (Adapted from FBrf0227776 and FBrf0152316).
Notes on Group

CG30160 is included in the TETRASPANINS gene group as it is a tandem duplicate of Tsp42Eb (FBrf0206967) and is identical within the coding region.

In FBrf0132356, CG31600 is reported as a Tetraspanin, although its sequence is highly divergent to other members, it possesses a four predicted transmembrane regions and is therefore tentatively included in the TETRASPANINS gene group.

Source Material
The TETRASPANINS Gene Group has been compiled using the following publication(s): Fox and Andrew, 2015, Jeibmann et al., 2015, Zhou et al., 2008, Fradkin et al., 2002, and Todres et al., 2000 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Cellular Component
membrane
Related Gene Groups
Other related group(s)
PASIFLORA PROTEINS
Members (38)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG30160
(Zhou et al., 2008)
CG31600
(Todres et al., 2000)
lbm
late bloomer
lbl
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
TM4SF
Transmembrane 4 superfamily
(Fox and Andrew, 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp2A
Tetraspanin 2A
EG:8D8.7
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp3A
Tetraspanin 3A
EG:BACR7C10.6
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp5D
Tetraspanin 5D
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp26A
Tetraspanin 26A
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp29Fa
Tetraspanin 29Fa
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp29Fb
Tetraspanin 29Fb
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp33B
Tetraspanin 33B
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp39D
Tetraspanin 39D
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp42A
Tetraspanin 42A
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp42Ea
Tetraspanin 42Ea
(Fox and Andrew, 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp42Eb
Tetraspanin 42Eb
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp42Ec
Tetraspanin 42Ec
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp42Ed
Tetraspanin 42Ed
BcDNA:GH07074
(Fox and Andrew, 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp42Ee
Tetraspanin 42Ee
BcDNA:LD16071
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp42Ef
Tetraspanin 42Ef
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp42Eg
Tetraspanin 42Eg
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp42Eh
Tetraspanin 42Eh
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp42Ei
Tetraspanin 42Ei
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp42Ej
Tetraspanin 42Ej
sun, Sunglasses
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp42Ek
Tetraspanin 42Ek
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp42El
Tetraspanin 42El
Tsp42E1
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp42En
Tetraspanin 42En
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp42Eo
Tetraspanin 42Eo
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp42Ep
Tetraspanin 42Ep
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp42Eq
Tetraspanin 42Eq
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp42Er
Tetraspanin 42Er
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp47F
Tetraspanin 47F
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp66A
Tetraspanin 66A
(Fox and Andrew, 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp66E
Tetraspanin 66E
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp68C
Tetraspanin 68C
(Fox and Andrew, 2015, Jeibmann et al., 2015, Todres et al., 2000)
Tsp74F
Tetraspanin 74F
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp86D
Tetraspanin 86D
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp96F
Tetraspanin 96F
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
Tsp97E
Tetraspanin 97E
(Fox and Andrew, 2015, Jeibmann et al., 2015, Fradkin et al., 2002, Todres et al., 2000)
External Data
Synonyms and Secondary IDs
Synonym(s)
TSP
TETRASPANINS
Tetraspans
Transmembrane 4 superfamily
TM4SF
Secondary FlyBase ID(s)
References (6)