FB2024_04 , released June 25, 2024
Gene Group: CONVENTIONAL MITOGEN ACTIVATED PROTEIN KINASES
Open Close
General Information
Name
CONVENTIONAL MITOGEN ACTIVATED PROTEIN KINASES
Species
D. melanogaster
Symbol
MAPK-C
FlyBase ID
FBgg0000244
Date last reviewed
2015-03-25
Number of members
5
Description
Description
Conventional Mitogen-activated protein kinases (MAPK) are proline-directed protein serine/threonine kinases that are components of the MAPK signaling cascade. MAPKs are activated by dual phosphorylation on Thr and Tyr residues within a conserved Thr-X-Tyr motif located in the activation loop by MAPK kinases. (Adapted from PMID:21372320).
Notes on Group

p38c was thought to be a pseudokinase due to divergence in kinase motifs (FBrf0182691), but has shown to have kinase activity experimentally by FBrf0226357.

Source Material
The CONVENTIONAL MITOGEN ACTIVATED PROTEIN KINASES Gene Group has been compiled using the following publication(s): Chakrabarti et al., 2014, Sopko et al., 2014, Manning et al., 2002, and Morrison et al., 2000 .
Key Gene Ontology (GO) terms
Molecular Function
MAP kinase activity
Biological Process
protein phosphorylation
MAPK cascade
Cellular Component
Enzymatic activity
Enzyme name (EC)
mitogen-activated protein kinase (2.7.11.24)
Related Gene Groups
Parent group(s)
MITOGEN ACTIVATED PROTEIN KINASES
Other related group(s)
STE KINASES
Members (5)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
bsk
basket
JNK, DJNK, c-Jun N-terminal kinase, Jun N-terminal kinase, pJNK
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
p38a
p38a MAP kinase
p38, Mpk2, D-p38a, Dp38, p38 MAPK
(Chakrabarti et al., 2014, Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
p38b
p38b MAP kinase
p38, D-p38b, p38β, p38Kb, p38 MAPK
(Chakrabarti et al., 2014, Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
p38c
p38c MAP kinase
p38, Mpk2B
(Chakrabarti et al., 2014, Sopko et al., 2014, Manning et al., 2002)
rl
rolled
ERK, MAPK, dpERK, MAP kinase, pERK
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
MAPK-C
CONVENTIONAL MITOGEN ACTIVATED PROTEIN KINASES
Classical MAP kinases
Conventional MAPK
Secondary FlyBase ID(s)
References (5)