FB2024_02 , released April 23, 2024
Gene Group: PROTEIN KINASE A FAMILY
Open Close
General Information
Name
PROTEIN KINASE A FAMILY
Species
D. melanogaster
Symbol
PKA
FlyBase ID
FBgg0000242
Date last reviewed
2015-03-25
Number of members
4
Description
Description
The Protein Kinase A (PKA) or cAMP-dependent protein kinases are serine/threonine kinases activated by cAMP. The PKA catalytic subunit is maintained in an inactive state in a heterotetrameric complex consisting of two catalytic (C) subunits bound to two regulatory (R) subunits. Binding of cAMP to the R subunits, releases the C subunits from inhibition. (Adapted from PMID:20027184).
Notes on Group
Source Material
The PROTEIN KINASE A FAMILY Gene Group has been compiled using the following publication(s): Sopko et al., 2014, Manning et al., 2002, and Morrison et al., 2000 .
Key Gene Ontology (GO) terms
Molecular Function
cAMP-dependent protein kinase activity
Biological Process
protein phosphorylation
Cellular Component
Enzymatic activity
Enzyme name (EC)
cAMP-dependent protein kinase (2.7.11.11)
Related Gene Groups
Parent group(s)
AGC-KINASES
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG12069
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Pka-C1
Protein kinase, cAMP-dependent, catalytic subunit 1
PKA, DC0, DCO, PKAc, protein kinase A
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Pka-C2
Protein kinase, cAMP-dependent, catalytic subunit 2
PKA, DC1, PKA C2
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Pka-C3
Protein kinase, cAMP-dependent, catalytic subunit 3
PKA, DC2, cAMP-dependent protein kinase 3, 5-23
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
PKA
PROTEIN KINASE A FAMILY
Cyclic AMP-dependent protein kinases
cAMP-dependent protein kinases
PKA isoforms
PKA catalytic subunits
PKAs
cAPK
Secondary FlyBase ID(s)
References (4)