FB2024_03 , released June 25, 2024
Gene Group: STE11 MAP KINASE KINASE KINASES
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General Information
Name
STE11 MAP KINASE KINASE KINASES
Species
D. melanogaster
Symbol
STE11-MAPKKK
FlyBase ID
FBgg0000218
Date last reviewed
2015-03-25
Number of members
2
Description
Description
STE11 MAP kinase kinase kinases (MAPKKKs) belong to the STE11 subfamily and are serine/threonine kinases that phosphorylate MAP kinase kinases in MAPK signalling cascades. MAPKKKs are activated by MAP kinase kinase kinase kinases (MAP4Ks). (Adapted from FBrf0225276.)
Notes on Group

Other MAPKKKs are found in the NON-RECEPTOR TLK KINASES and GERMINAL CENTER KINASES groups.

Source Material
The STE11 MAP KINASE KINASE KINASES Gene Group has been compiled using the following publication(s): Sopko et al., 2014, Manning et al., 2002, and Morrison et al., 2000 .
Key Gene Ontology (GO) terms
Molecular Function
MAP kinase kinase kinase activity
Biological Process
protein phosphorylation
MAPK cascade
Cellular Component
Enzymatic activity
Enzyme name (EC)
mitogen-activated protein kinase kinase kinase (2.7.11.25)
Related Gene Groups
Parent group(s)
STE KINASES
Other related group(s)
GERMINAL CENTER KINASES
NON-RECEPTOR TYROSINE KINASES
Members (2)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Ask1
Apoptotic signal-regulating kinase 1
Pk92B, DASK1
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
Mekk1
Mekk1
dMEKK1, D-MEKK1, MEKK4
(Sopko et al., 2014, Manning et al., 2002, Morrison et al., 2000)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
STE11-MAPKKK
Mitogen-activated protein kinase kinase kinases
STE11 kinases
MAP kinase kinase kinase
STE11
MAP3K
MAPKKK
MEKK
STE11 KINASES (MAPK KINASE KINASES)
STE11 MAP KINASE KINASE KINASES
Secondary FlyBase ID(s)
References (4)