FB2024_03 , released June 25, 2024
FB2024_03 , released June 25, 2024
CV Term Report
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General Information
Term medullary intrinsic neuron Mi1 ID (Ontology) FBbt:00003776 (Fly Anatomy)
Definition Unicolumnar medullary intrinsic neuron with bushy, fine arborizations in medulla layers M1, M5 and M9-10 (Fischbach and Dittrich, 1989; Kind et al., 2021). The projection of this neuron branches at the inner-face of the medulla to form two to three varicose recurrent terminal specializations that extend back up to the inner border of layer M8 (Fischbach and Dittrich, 1989; Morante and Desplan, 2008). In central (non-dorsal margin) columns it receives input from an R8 photoreceptor cell, but connections are substantially weaker in dorsal margin columns (Kind et al., 2021). Pre-synaptic terminals are present mainly in medulla layers M9-M10, but also in all other layers where neurites extend laterally (Pankova and Borst, 2017). It receives input from lamina monopolar neurons L1 and L5 and centrifugal neuron C2 (Takemura et al., 2013). It outputs to T4 neurons and transmedullary neuron Tm3a (Takemura et al., 2013). It is a cholinergic neuron (Hasegawa et al., 2011; Pankova and Borst, 2017).[ FlyBase:FBrf0049410 FlyBase:FBrf0204652 FlyBase:FBrf0213020 FlyBase:FBrf0222324 FlyBase:FBrf0235353 FlyBase:FBrf0252485 ]
Also Known As "medullary intrinsic neuron 1" ; "Mi1"
Comment Pre-synaptic terminals were assessed by labelling with a UAS-Synaptotagmin reporter (P\{UAS-HA-syt\} - FBtp0015803). The neurotransmitter was assessed by labelling cells with an anti-ChAT antibody (Hasegawa et al., 2011). The morphology of the terminals was judged from figures in Fischbach and Dittrich (1989) as assessed by FlyBrain Neuron DB. Connectivity and morphology in the medulla were assessed by electron microscopy reconstruction from 7 columns (Takemura et al., 2013).
Links to Extrernal Ontologies
VFB:FBbt_00003776
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  PHENOTYPE_MANIFEST_IN      26
Insertions (FBti)  EXPRESSION_STAGE_TISSUE_POSITION       3
Insertions (FBti)  PHENOTYPE_MANIFEST_IN       2
Constructs (FBtp)  PHENOTYPE_MANIFEST_IN      13
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 Full annotation statements 
Relevant FlyBase reports
 Alleles  Genes Insertions Constructs
 medullary intrinsic neuron Mi1 (all annotations which use CV term, excluding "NOT" statements)      29      3      4      5     27
     medullary intrinsic neuron Mi1 | adult stage       3       --       --       --       3
     medullary intrinsic neuron Mi1 | ectopic       3       --       --       --       2
     medullary intrinsic neuron Mi1 | larval stage       4       --       --       --       4
     medullary intrinsic neuron Mi1 | larval stage | somatic clone       2       --       --       --       2
     medullary intrinsic neuron Mi1 | P-stage       3       --       --       1       --
     medullary intrinsic neuron Mi1 | P-stage | somatic clone       8       --       --       --       6
     medullary intrinsic neuron Mi1 | pupal stage       1       --       --       --       --
     medullary intrinsic neuron Mi1 | pupal stage | somatic clone       1       --       --       --       --
     medullary intrinsic neuron Mi1 | somatic clone       5       --       --       1       --
Spanning Tree (Parents/Children)
Only view relationship: 
adult optic lobe columnar neuron
 |__optic lobe narrow field columnar neuron__
cholinergic neuron                           |
 |__adult cholinergic neuron_________________|
optic lobe intrinsic columnar neuron         |
 |__medullary intrinsic neuron_______________|
adult neuron                                 |
 |__adult cholinergic neuron_________________|
secondary neuron                             |
 |__Notch ON hemilineage secondary neuron____|
Notch ON hemilineage neuron                  |
 |__Notch ON hemilineage secondary neuron____|
                                             medullary intrinsic neuron Mi1  68 rec.
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Is a medullary intrinsic neuron
Notch ON hemilineage secondary neuron
adult cholinergic neuron
optic lobe narrow field columnar neuron
Develops from immature medullary intrinsic neuron Mi1
Part of
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Synonyms
  • "medullary intrinsic neuron 1" EXACT
    "Mi1" EXACT VFB_SYMBOL[ FlyBase:FBrf0247762 ]
    "small field unilateral tristratified neuron" RELATED
    "Sut" RELATED
Secondary IDs
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FlyBrain_NDB:10097
VFB:FBbt_00003776