FlyBase Allele Report: Dmel\Ir20a[UAS.cGa]

General Information

Symbol

Dmel\Ir20a^UAS.cGa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Ganguly

FlyBase ID

FBal0325467

Feature type

allele

Associated gene

Dmel\Ir20a

Associated Insertion(s)

Carried in Construct

P{UAS-Ir20a.G}

Key Links

Transgenic product class

wild_type

(Ganguly et al., 2017)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Ganguly et al., 2017)

Mutagen

in vitro construct

(Ganguly et al., 2017)

Progenitor genotype

Carried in construct

P{UAS-Ir20a.G}

Cytology

Description

UAS regulatory sequences drive expression of the full-length Ir20a coding sequence.

(Ganguly et al., 2017)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Ir20a

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | adult stage, with Scer\GAL4^Ir76b.1.5

(Ganguly et al., 2017)

abnormal taste perception | adult stage, with Scer\GAL4^Ir76b.1.5

(Ganguly et al., 2017)

Phenotype Manifest In

gustatory receptor neuron | adult stage, with Scer\GAL4^Ir76b.1.5

(Ganguly et al., 2017)

Detailed Description

Statement

Reference

L-type labellar sensilla in flies expressing Ir20a^Scer\UAS.cGa under the control of Scer\GAL4^Ir76b.1.5 show a drastically reduced sweet-taste neuron response to salt as compared to controls.

(Ganguly et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Ir20a^UAS.cGa, Ir76b², Ir76b^UAS.cAa, Scer\GAL4^Gr5a.8.5 has abnormal neurophysiology phenotype

(Ganguly et al., 2017)

Ir20a^UAS.cGa, Ir76b², Ir76b^UAS.cAa, Scer\GAL4^Gr5a.8.5 has abnormal taste perception | adult stage phenotype

(Ganguly et al., 2017)

Phenotype Manifest In

Other

Statement

Reference

Ir20a^UAS.cGa, Ir76b², Ir76b^UAS.cAa, Scer\GAL4^Gr5a.8.5 has gustatory receptor neuron phenotype

(Ganguly et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

In a taste response assay with responses measured by single sensillum recordings, co-expression of Ir76b^Scer\UAS.cAa and Ir20a^Scer\UAS.cGa under the control of Scer\GAL4^Gr5a.8.5 in a Ir76b²/Ir76b² mutant background leads to sweet-taste neurons in L-type sensilla becoming sensitive to a mixture of serine, threonine and phenylalanine, in contrast to controls; and suppresses the response to salt in sweet-taste neurons of L-type labellar sensilla, as compared to Ir76b²/Ir76b² mutants expressing Ir76b^Scer\UAS.cAa alone.

(Ganguly et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Ir20a^Scer\UAS.cGa

Ir20a^UAS.cGa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Ganguly

Secondary FlyBase IDs

References (1)

Report Sections

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