The destabilization domain of human FKBP12 has been described in Banaszynski et al. (2006) "A Rapid, Reversible, and Tunable Method to Regulate Protein Function in Living Cells Using Synthetic Small Molecules", Cell 126: 995–1004 (PMID:16959577). Degradation of the mCherry fusion protein is inhibited in vivo by feeding larvae the small molecule inhibitor Shield-1.
The destabilization domain of human FKBP12 has been described in Banaszynski et al. (2006) "A Rapid, Reversible, and Tunable Method to Regulate Protein Function in Living Cells Using Synthetic Small Molecules", Cell 126: 995–1004 (PMID:16959577). Degradation of the mCherry fusion protein is inhibited in vivo by feeding larvae the small molecule inhibitor Shield-1.