FB2024_04 , released June 25, 2024
Allele: Dmel\Ctr1CUAS.cLa
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General Information
Symbol
Dmel\Ctr1CUAS.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Lang
FlyBase ID
FBal0288239
Feature type
allele
Associated gene
Dmel\Ctr1C
Associated Insertion(s)
Carried in Construct
P{UAS-Ctr1C.L}
Key Links
Transgenic product class
wild_type
(Lang et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Lang et al., 2013)
Mutagen
in vitro construct
(Lang et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Ctr1C.L}
Cytology
Description

UASt regulatory sequences drive expression of Ctr1C.

(Lang et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Ctr1C
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Ctr1CScer\UAS.cLa under the control of Scer\GAL4elav.PU results in animals dying as second or third instar larvae when they are fed normal food at 35[o]C. This lethality is rescued in a dose-dependent manner by supplementing the food with the copper chelator bathocuproine disulfonate (BCS), with almost 100% rescue at a concentration of 500 μmol/L BCS. The lethality is not rescued by supplementing the food with EDTA.

      Animals expressing Ctr1CScer\UAS.cLa under the control of Scer\GAL4elav.PU at 18[o]C survive to adulthood but have an abnormal wing phenotype and rough eyes.

      (Lang et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ctr1CScer\UAS.cLa
      Ctr1CUAS.cLa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Lang
      Secondary FlyBase IDs
        References (1)