FB2024_03 , released June 25, 2024
Allele: Dmel\PcbCB-0292-3
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General Information
Symbol
Dmel\PcbCB-0292-3
Species
D. melanogaster
Name
FlyBase ID
FBal0221900
Feature type
allele
Associated gene
Dmel\Pcb
Associated Insertion(s)
P{RS3}PcbCB-0292-3
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Yamazaki et al., 2014)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{RS3}PcbCB-0292-3
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Also carries
    FRT
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        PCBCB-0292-3/PCBCB-0292-3 is semi-lethal and adult flies show severe reductions in 1hr memory. PCBCB-0292-3/+ heterozygotes are viable, show significant 1hr memory defects compared to wild type (1 day old) and show significant suppression of age-related memory impairment (AMI) seen in wild type (15 days and older).

        (Yamazaki et al., 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        CG1516CB-0292-3
        PCBCB-0292-3
        PcbCB-0292-3
        dPCCB0292-3
        (Yamazaki et al., 2014)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)