FlyBase Allele Report: Dmel\Ilp5[UAS.cIa]

General Information

Symbol

Dmel\Ilp5^UAS.cIa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Ikeya

FlyBase ID

FBal0141673

Feature type

allele

Associated gene

Dmel\Ilp5

Associated Insertion(s)

Carried in Construct

P{UAS-Ilp5.I}

Also Known As

UAS-Dilp5

Key Links

Transgenic product class

wild_type

(Ikeya et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Ikeya et al., 2002)

Mutagen

in vitro construct

(Ikeya et al., 2002)

Progenitor genotype

Carried in construct

P{UAS-Ilp5.I}

Cytology

Description

UASt sequences drive expression of Ilp5.

(Ikeya et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Ilp5

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical resistant, with Scer\GAL4^Ilp2.PR

(McClure et al., 2011)

increased body size, with Scer\GAL4^arm.PS

(Ikeya et al., 2002)

increased occurrence of cell division | second instar larval stage, with Scer\GAL4^repo.PU

(Sousa-Nunes et al., 2011)

Phenotype Manifest In

larval neuroblast, with Scer\GAL4^repo.PU

(Sousa-Nunes et al., 2011)

Detailed Description

Statement

Reference

Expression of Ilp5^Scer\UAS.cIa in the insulin producing cells (IPCs) under the control of Scer\GAL4^Ilp2.PR ameliorates both the lethality and developmental delay phenotypes associated with developmental ethanol exposure.

(McClure et al., 2011)

Central nervous system neuroblasts of fed second instar larvae expressing Ilp5^Scer\UAS.cIa under the control of Scer\GAL4^repo.PU show an increase in EdU incorporation compared to controls.

Expression of Ilp5^Scer\UAS.cIa under the control of Scer\GAL4^repo.PU does not affect the body mass of third instar larvae.

(Sousa-Nunes et al., 2011)

When Ilp5^Scer\UAS.cIa is driven by Scer\GAL4^arm.PS or Scer\GAL4^Act5C.PP a statistically significant increase in body size is seen.

(Ikeya et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Ilp5^Scer\UAS.cHa

Ilp5^Scer\UAS.cIa

Ilp5^UAS.cIa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Ikeya

(Ikeya et al., 2002)

Secondary FlyBase IDs

References (9)

Report Sections

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