FB2024_03 , released June 25, 2024
Allele: Dmel\pxbUAS.cIa
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General Information
Symbol
Dmel\pxbUAS.cIa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Inaki
FlyBase ID
FBal0138165
Feature type
allele
Associated gene
Dmel\pxb
Associated Insertion(s)
Carried in Construct
P{UAS-pxb.I}
Key Links
Transgenic product class
cDNA
(Inaki et al., 2002)
wild_type
(Inaki et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Inaki et al., 2002)
wild_type
(Inaki et al., 2002)
Mutagen
in vitro construct
(Inaki et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-pxb.I}
Cytology
Description

UASt sequences drive expression of a 3kb long pxb cDNA fragment.

(Inaki et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
pxb
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When pxbScer\UAS.cIa is driven by Scer\GAL4Dll-em212 Scer\GAL4hh-Gal4 or Scer\GAL4ptc-559.1 cuticle defects are seen in the medial region of all three leg types. The region of tarsal segment 5 flanked by longitudinal bristle rows 1 and 8 show a significant loss of microchaetae in a dose dependant manner. Raising the temperature from 25 to 29oC gives no appreciable effects on hair reduction. No loss of the distal-most sensory bristle is seen. When pxbScer\UAS.cIa is driven by Scer\GAL4ptc-559.1 a reduction in the number of scutellar bristles is seen. Animals have 2.8 bristles on average (compared to 4 in wild-type and 4.3 in homozygous Scer\GAL4ptc-559.1 animals) and only a quarter of animals possess 4 bristles.

      (Inaki et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      pxbScer\UAS.cIa
      pxbUAS.cIa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Inaki
      (Inaki et al., 2002)
      Secondary FlyBase IDs
        References (1)