FB2024_04 , released June 25, 2024
Allele: Dmel\E(spl)m4-BFMUAS.cLa
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General Information
Symbol
Dmel\E(spl)m4-BFMUAS.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Lai
FlyBase ID
FBal0103662
Feature type
allele
Associated gene
Dmel\E(spl)m4-BFM
Associated Insertion(s)
Carried in Construct
P{UAS-E(spl)m4-BFM.L}
Key Links
Transgenic product class
wild_type
(Lai et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Lai et al., 2000)
Mutagen
in vitro construct
(Lai et al., 2000)
Progenitor genotype
Carried in construct
P{UAS-E(spl)m4-BFM.L}
Cytology
Description

UASt regulatory sequences drive expression of the coding region and a few nucleotides of 5' UTR sequence (to provide translational initiation context) of E(spl)m4-BFM.

(Lai et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
E(spl)m4-BFM
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing m4Scer\UAS.cLa under the control of Scer\GAL4sca-537.4 show defects in the adult peripheral nervous system similar to that seen when BrdScer\UAS.cLa is expressed under the control of Scer\GAL4sca-537.4, although the degree of bristle multiplication is slightly greater. Flies expressing high levels of m4Scer\UAS.cLa under the control of Scer\GAL4ey.PS show strong defects in ommatidial assembly and organisation, showing substantial ommatidial fusion and lens pitting in the eye. Expression of m4Scer\UAS.cLa under the control of either Scer\GAL4Bx-MS1096 or Scer\GAL469B does not appear to alter wing vein fates or the overall integrity of the wing margin, although sensory organ fates in each of these territories are altered.

      (Lai et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      E(spl)m4-BFMScer\UAS.cLa
      E(spl)m4-BFMUAS.cLa
      m4Scer\UAS.cLa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Lai
      (Lai et al., 2000)
      Secondary FlyBase IDs
        References (1)