FlyBase Allele Report: Dmel\sog[UAS.cYa]

Expression of sog^Scer\UAS.cYa under the control of either Scer\GAL4^ptc-559.1 or Scer\GAL4^Bx-MS1096 results in a modest loss of wing vein phenotype.

(Kang and Bier, 2010)

Expression of sog^Scer\UAS.cYa driven by either Scer\GAL4^Bx-MS1096 or Scer\GAL4^ptc-559.1 prevents formation of the anterior crossvein (ACV). Scer\GAL4^en-e16E driven expression of sog^Scer\UAS.cYa causes loss of the posterior crossvein in addition to ACV.

Expression of sog^Scer\UAS.cYa in a subset of the wing cells driven with either Scer\GAL4^ptc-559.1 or Scer\GAL4^en-e16E triggers the appearance of ectopic crossvein material. In contrast, no ectopic vein appears when sog^Scer\UAS.cYa is expressed throughout the entire wing blade with Scer\GAL4^Bx-MS1096.

Supernumerary scutellar bristles are induced in response to expression of sog^Scer\UAS.cYa driven by Scer\GAL4^ptc-559.1.

(Evans et al., 2009)

Expression of sog^Scer\UAS.cYa under the control of Scer\GAL4^en-e16E results in loss of the posterior crossvein.

(Serpe et al., 2008)

Expression of sog^Scer\UAS.cYa under the control of Scer\GAL4^69B results in a loss of posterior crossvein tissue.

(Zeng et al., 2007)

Expression of sog^Scer\UAS.cYa under the control of Scer\GAL4^hs.PB, following a 1 hour heat shock between 16 and 21 hours after pupariation (AP), disrupts the posterior crossvein in the wing. The phenotype is most penetrant when heat shock is applied at 17-18 hours AP. No defects are observed if the heat shock is applied at any other stage of development and the anterior crossvein is never affected. Overexpression of sog^Scer\UAS.cYa in the posterior of the wing, under the control of Scer\GAL4^en-e16E, causes loss of crossveins in adult flies.

(Ralston and Blair, 2005)

Expression of sog^Scer\UAS.cYa under the control of Scer\GAL4^Bx-MS1096 results in mild truncation of the wing veins although patterning of the anterior/posterior axis in the wing is normal.

(Yu et al., 2004)

Embryos expressing sog^Scer\UAS.cYa under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} lack amnioserosa cells.

(Dorfman and Shilo, 2001)

Misexpression driven by Scer\GAL4^CY2 or Scer\GAL4^55B does not generate any eggshell defects, though misexpression driven by Scer\GAL4^CY2 affects embryonic DV patterning in that the denticle belts are expanded to a more dorsal position than normal.

(Araujo and Bier, 2000)

When sog^Scer\UAS.cYa expression is driven by Scer\GAL4^en-e16E, adult wings lack anterior and posterior cross veins, but the ends of the longitudinal veins are still formed.

(Conley et al., 2000)

Expression of sog^Scer\UAS.cYa under the control of either Scer\GAL4^dpp.blk1, Scer\GAL4^72B or Scer\GAL4^Bx-MS1096 results in moderate wing vein truncations.

(Yu et al., 2000)

Flies expressing two copies of sog^Scer\UAS.cYa under the control of Scer\GAL4^A9 sometimes show loss of the posterior crossvein.

(Nguyen et al., 1998)

Scer\GAL4^32B mediated expression causes consistent lack of the anterior half of the posterior crossvein and the distal tips of wing veins L4 and L5. Scer\GAL4^69B mediated expression causes loss of both crossveins and the distal tips of wing veins L2 to L5.

(Yu et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^A9, sog^UAS.cYa has visible phenotype, enhanceable by Scer\GAL4^A9/tsg^UAS.cYa

(Peluso et al., 2011)

Scer\GAL4^ptc-559.1, sog^UAS.cYa has visible phenotype, enhanceable by kek5^fe148/kek5^fe148

(Evans et al., 2009)

Suppressed by

Statement

Reference

Scer\GAL4^A9, sog^UAS.cYa, tsg^UAS.cYa has visible phenotype, suppressible by Scer\GAL4^A9/tok^{UAS.cSa.Tag:HA}

(Peluso et al., 2011)

Scer\GAL4^ptc-559.1, sog^UAS.cYa has visible phenotype, suppressible by Scer\GAL4^ptc-559.1/kek5^UAS.GFP

(Evans et al., 2009)

Scer\GAL4^en-e16E, sog^UAS.cYa has visible phenotype, suppressible | partially by Scer\GAL4^en-e16E/cv-2^N.UAS.EGFP

(Serpe et al., 2008)

Scer\GAL4^A9, dpp^UAS.cHa, sog^UAS.cYa has visible phenotype, suppressible by Scer\GAL4^A9/tsg^UAS.cYa

(Ross et al., 2001)

Suppressor of

Statement

Reference

Scer\GAL4^ptc-559.1/sog^UAS.cYa is a suppressor of visible phenotype of Scer\GAL4^ptc-559.1, gbb^UAS.cKa

(Kang and Bier, 2010)

Scer\GAL4^A9, sog^UAS.cYa, tsg^UAS.cYa is a suppressor | partially of visible phenotype of Scer\GAL4^A9, dpp^UAS.cHa

(Ross et al., 2001)

Scer\GAL4^A9/sog^UAS.cYa is a suppressor of visible phenotype of Scer\GAL4^A9, dpp^UAS.cHa, tsg^UAS.cYa

(Ross et al., 2001)

Scer\GAL4^A9/sog^UAS.cYa is a suppressor of visible phenotype of Scer\GAL4^A9, gbb^UAS.cKa

(Yu et al., 2000)

sog^UAS.cYa is a suppressor of visible phenotype of Scer\GAL4^A9, scw^UAS.cNa

(Nguyen et al., 1998)

NOT Suppressor of

Statement

Reference

Scer\GAL4^A9/sog^UAS.cYa is a non-suppressor of visible phenotype of Scer\GAL4^A9, dpp^UAS.cHa

(Ross et al., 2001, Nguyen et al., 1998)

Other

Statement

Reference

Scer\GAL4^A9, dpp^UAS.cHa, sog^UAS.cYa has visible phenotype

(Ross et al., 2001)

Scer\GAL4^A9, sog^UAS.cYa, tsg^UAS.cYa has visible phenotype

(Ross et al., 2001)

Mmus\Twsg1^UAS.cRa, Scer\GAL4^A9, sog^UAS.cYa has visible phenotype

(Ross et al., 2001)

Hsap\TWSG1^UAS.cRa, Scer\GAL4^A9, sog^UAS.cYa has visible phenotype

(Ross et al., 2001)

Scer\GAL4^unspecified, sog^UAS.cYa, tsg^UAS.cYa has visible phenotype

(Yu et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^A9, sog^UAS.cYa has wing vein phenotype, enhanceable by Scer\GAL4^A9/tsg^UAS.cYa

(Peluso et al., 2011)

Scer\GAL4^ptc-559.1, sog^UAS.cYa has crossvein phenotype, enhanceable by kek5^fe148/kek5^fe148

(Evans et al., 2009)

Suppressed by

Statement

Reference

Scer\GAL4^A9, sog^UAS.cYa, tsg^UAS.cYa has wing blade phenotype, suppressible by Scer\GAL4^A9/tok^{UAS.cSa.Tag:HA}

(Peluso et al., 2011)

Scer\GAL4^A9, sog^UAS.cYa, tsg^UAS.cYa has wing vein phenotype, suppressible by Scer\GAL4^A9/tok^{UAS.cSa.Tag:HA}

(Peluso et al., 2011, Serpe et al., 2005)

Scer\GAL4^ptc-559.1, sog^UAS.cYa has crossvein phenotype, suppressible by Scer\GAL4^ptc-559.1/kek5^UAS.GFP

(Evans et al., 2009)

Scer\GAL4^en-e16E, sog^UAS.cYa has posterior crossvein phenotype, suppressible | partially by Scer\GAL4^en-e16E/cv-2^N.UAS.EGFP

(Serpe et al., 2008)

Scer\GAL4^en-e16E, sog^UAS.cYa has crossvein phenotype, suppressible by Scer\GAL4^en-e16E/cv-2^EP1103

(Ralston and Blair, 2005)

Scer\GAL4^A9, sog^UAS.cYa, tsg^UAS.cYa has wing phenotype, suppressible by Scer\GAL4^A9/tld^A.UAS.Tag:HA

(Serpe et al., 2005)

Scer\GAL4^A9, sog^UAS.cYa, tsg^UAS.cYa has wing vein phenotype, suppressible by Scer\GAL4^A9/tld^A.UAS.Tag:HA

(Serpe et al., 2005)

Scer\GAL4^A9, sog^UAS.cYa, tsg^UAS.cYa has wing phenotype, suppressible by Scer\GAL4^A9/tok^{UAS.cSa.Tag:HA}

(Serpe et al., 2005)

Scer\GAL4^A9, dpp^UAS.cHa, sog^UAS.cYa has wing vein phenotype, suppressible by Scer\GAL4^A9/tsg^UAS.cYa

(Ross et al., 2001)

Scer\GAL4^A9, dpp^UAS.cHa, sog^UAS.cYa has wing phenotype, suppressible by Scer\GAL4^A9/tsg^UAS.cYa

(Ross et al., 2001)

NOT suppressed by

Statement

Reference

Scer\GAL4^A9, cv^UAS.cVa, sog^UAS.cYa has wing phenotype, non-suppressible by dpp^UAS.cHa/Scer\GAL4^A9

(Vilmos et al., 2005)

Suppressor of

Statement

Reference

Scer\GAL4^ptc-559.1/sog^UAS.cYa is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^ptc-559.1, gbb^UAS.cKa

(Kang and Bier, 2010)

Scer\GAL4^A9, sog^UAS.cYa, tsg^UAS.cYa is a suppressor of wing phenotype of Scer\GAL4^A9, gbb^UAS.cKa

(Vilmos et al., 2005)

Scer\GAL4^A9, sog^UAS.cYa, tsg^UAS.cYa is a suppressor | partially of wing vein phenotype of Scer\GAL4^A9, dpp^UAS.cHa

(Ross et al., 2001)

Scer\GAL4^A9, sog^UAS.cYa, tsg^UAS.cYa is a suppressor | partially of wing phenotype of Scer\GAL4^A9, dpp^UAS.cHa

(Ross et al., 2001)

Scer\GAL4^A9/sog^UAS.cYa is a suppressor of wing vein phenotype of Scer\GAL4^A9, dpp^UAS.cHa, tsg^UAS.cYa

(Ross et al., 2001)

Scer\GAL4^A9/sog^UAS.cYa is a suppressor of wing phenotype of Scer\GAL4^A9, dpp^UAS.cHa, tsg^UAS.cYa

(Ross et al., 2001)

Scer\GAL4^A9/sog^UAS.cYa is a suppressor of wing cell phenotype of Scer\GAL4^A9, gbb^UAS.cKa

(Yu et al., 2000)

Scer\GAL4^A9/sog^UAS.cYa is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^A9, gbb^UAS.cKa

(Yu et al., 2000)

Scer\GAL4^A9/sog^UAS.cYa is a suppressor of wing phenotype of Scer\GAL4^A9, gbb^UAS.cKa

(Yu et al., 2000)

sog^UAS.cYa is a suppressor of wing phenotype of Scer\GAL4^A9, scw^UAS.cNa

(Nguyen et al., 1998)

NOT Suppressor of

Statement

Reference

Scer\GAL4^A9, sog^UAS.cYa, cv^UAS.cVa is a non-suppressor of wing phenotype of Scer\GAL4^A9, dpp^UAS.cHa

(Vilmos et al., 2005)

Scer\GAL4^A9/sog^UAS.cYa is a non-suppressor of wing phenotype of Scer\GAL4^A9, dpp^UAS.cHa

(Ross et al., 2001, Nguyen et al., 1998)

Scer\GAL4^A9/sog^UAS.cYa is a non-suppressor of wing vein phenotype of Scer\GAL4^A9, dpp^UAS.cHa

(Ross et al., 2001, Yu et al., 2000)

Other

Statement

Reference

Scer\GAL4^A9, sog^UAS.cYa, tsg^UAS.cYa has wing blade phenotype

(Peluso et al., 2011)

Scer\GAL4^A9, sog^UAS.cYa, tsg^UAS.cYa has wing vein phenotype

(Serpe et al., 2005, Ross et al., 2001)

Scer\GAL4^A9, sog^UAS.cYa, tsg^UAS.cYa has wing phenotype

(Serpe et al., 2005)

Scer\GAL4^en-e16E, cv^EP1349, sog^UAS.cYa has wing vein | ectopic phenotype

(Shimmi et al., 2005)

Scer\GAL4^en-e16E, cv^EP1349, sog^UAS.cYa has wing vein phenotype

(Shimmi et al., 2005)

Scer\GAL4^A9, cv^{UAS.Tag:polyHis}, sog^UAS.cYa has wing phenotype

(Shimmi et al., 2005)

Scer\GAL4^A9, cv^{UAS.Tag:polyHis}, sog^UAS.cYa has wing vein phenotype

(Shimmi et al., 2005)

Scer\GAL4^A9, cv^UAS.cVa, gbb^UAS.cKa, sog^UAS.cYa has crossvein phenotype

(Vilmos et al., 2005)

Scer\GAL4^en-e16E, cv^UAS.cVa, sog^UAS.cYa has wing | posterior phenotype

(Vilmos et al., 2005)

Scer\GAL4^A9, cv^UAS.cVa, sog^UAS.cYa has wing phenotype

(Vilmos et al., 2005)

Scer\GAL4^A9, cv^UAS.cVa, sog^UAS.cYa has wing cell phenotype

(Vilmos et al., 2005)

Scer\GAL4^ptc-559.1, cv^UAS.cVa, sog^UAS.cYa has wing phenotype

(Vilmos et al., 2005)

Scer\GAL4^Bx-MS1096, sog^UAS.cYa, tsg^UAS.cYa has wing phenotype

(Yu et al., 2004)

Scer\GAL4^A9, dpp^UAS.cHa, sog^UAS.cYa has wing vein phenotype

(Ross et al., 2001)

Mmus\Twsg1^UAS.cRa, Scer\GAL4^A9, sog^UAS.cYa has wing vein phenotype

(Ross et al., 2001)

Hsap\TWSG1^UAS.cRa, Scer\GAL4^A9, sog^UAS.cYa has wing vein phenotype

(Ross et al., 2001)

Scer\GAL4^A9, dpp^UAS.cHa, sog^UAS.cYa has wing phenotype

(Ross et al., 2001)

Scer\GAL4^unspecified, sog^UAS.cYa, tsg^UAS.cYa has wing phenotype

(Yu et al., 2000)

Scer\GAL4^unspecified, sog^UAS.cYa, tsg^UAS.cYa has wing vein phenotype

(Yu et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Overexpression of sog^Scer\UAS.cYa together with tsg^Scer\UAS.cYa under the control of Scer\GAL4^A9 results in smaller wings with altered patterns of venation.

Co-overexpression of tok^{Scer\UAS.cSa.T:Ivir\HA1} with sog^Scer\UAS.cYa and tsg^Scer\UAS.cYa under the control of Scer\GAL4^A9 is able to reverse the sog^Scer\UAS.cYa-tsg^Scer\UAS.cYa small-wing phenotype and restore normal patterning.

(Peluso et al., 2011)

Co-expression of sog^Scer\UAS.cYa suppresses the ectopic wing vein phenotype caused by expression of gbb^Scer\UAS.cKa under the control of Scer\GAL4^ptc-559.1.

Co-expression of sog^Scer\UAS.cYa does not suppress the ectopic wing vein phenotype caused by expression of sax^A.Scer\UAS under the control of Scer\GAL4^Bx-MS1096.

(Kang and Bier, 2010)

The ectopic crossvein phenotype in wings expressing sog^Scer\UAS.cYa driven by Scer\GAL4^ptc-559.1 is enhanced by kek5^fe148. A full-length ectopic crossvein appears between L4 and L5 in 33% of wings expressing sog^Scer\UAS.cYa driven by Scer\GAL4^ptc-559.1 in a homozygous kek5^fe148 background.

The ectopic crossvein phenotype in wings expressing sog^Scer\UAS.cYa driven by Scer\GAL4^ptc-559.1 can be suppressed by co-expressing kek5^{Scer\UAS.T:Avic\GFP}.

(Evans et al., 2009)

Expression of cv-2^{N.Scer\UAS.T:Avic\GFP-EGFP} partially rescues the posterior crossvein loss seen in the wings of flies expressing sog^Scer\UAS.cYa under the control of Scer\GAL4^en-e16E.

(Serpe et al., 2008)

The loss of crossvein phenotype can be rescued when cv-2^EP1103 is expressed under the control of Scer\GAL4^en-e16E, along with sog^Scer\UAS.cYa expression.

(Ralston and Blair, 2005)

Coexpression of sog^Scer\UAS.cYa and tsg^Scer\UAS.cYa in the wing disc, under the control of Scer\GAL4^A9, produces a small wing with altered patterns of venation. Coexpression of either tld^{A.Scer\UAS.T:Ivir\HA1} or tok^Scer\UAS.cSa with these two transgenes is able to reverse the small wing phenotype and restore normal patterning.

(Serpe et al., 2005)

Co-expression of cv^{Scer\UAS.T:Zzzz\His6} and sog^Scer\UAS.cYa, both under the control of Scer\GAL4^A9, results in small wings and disrupted wing vein formation. Co-expression of sog^Scer\UAS.cYa and cv^EP1349 in the posterior compartment of the wing, driven by Scer\GAL4^en-e16E, results in truncation of longitudinal veins in this compartment and the appearance of ectopic veins in the anterior compartment.

(Shimmi et al., 2005)

When cv^Scer\UAS.cVa and sog^Scer\UAS.cYa are co-expressed under the regulation of Scer\GAL4^A9, there is strong BMP inhibition. Co-expression of cv^Scer\UAS.cVa and sog^Scer\UAS.cYa under the regulation of Scer\GAL4^A9 produces a phenotype resembling early loss of BMP signalling in the organiser that runs along the anterior-posterior boundary (i.e. reduction in size and loss of intervein regions). Co-expression of cv^Scer\UAS.cVa and sog^Scer\UAS.cYa along the anterior-posterior boundary under the regulation of Scer\GAL4^ptc-559.1, affects structures throughout the wing, whereas co-expression in the posterior compartment under the regulation of Scer\GAL4^en-e16E affects only posterior structures. Co-expression of cv^Scer\UAS.cVa and sog^Scer\UAS.cYa, with dpp^Scer\UAS.cHa, under the regulation of Scer\GAL4^A9 has no detectable effect on the overexpression phenotype of dpp^Scer\UAS.cHa (wing disruption). Co-expression of sog^Scer\UAS.cYa and dpp^Scer\UAS.cHa, under the regulation of Scer\GAL4^A9 has no detectable effect on the over expression phenotype of dpp^Scer\UAS.cHa, indicating that sog alone does not interact with dpp. Co-expression of sog^Scer\UAS.cYa with gbb^Scer\UAS.cKa, under the regulation of Scer\GAL4^A9 has no detectable effect on the overexpression phenotype of gbb^Scer\UAS.cKa (wing disruption). Co-expression of cv^Scer\UAS.cVa and sog^Scer\UAS.cYa, with gbb^Scer\UAS.cKa, under the regulation of Scer\GAL4^A9 re-establishes the intervein tissue and the longitudinal veins with a series of expanded crossveins between L2 and L3 on the wing. Therefore, cv and sog interact together to suppress the wing phenotype of gbb. Co-expression of sog^Scer\UAS.cYa and tsg^Scer\UAS.cYa, along with dpp^Scer\UAS.cHa, under the regulation of Scer\GAL4^A9 results in rescue of the effect of excess dpp (wing disruption). Co-expression of tsg^Scer\UAS.cYa and sog^Scer\UAS.cYa, along with gbb^Scer\UAS.cKa, under the regulation of Scer\GAL4^A9 partially suppresses the excess gbb^Scer\UAS.cKa wing disruption phenotype.

(Vilmos et al., 2005)

Expression of sog^Scer\UAS.cYa and tsg^Scer\UAS.cYa, but not either alone, driven by Scer\GAL4^A9 rescues the wing shape and wing vein phenotype of dpp^Scer\UAS.cHa driven by Scer\GAL4^A9.

(Ross et al., 2001)

Expression of gbb^Scer\UAS.cKa under the control of Scer\GAL4^A9 produces slightly broadened wings consisting of solid veins. This solid vein phenotype is strongly suppressed by co-expression of sog^Scer\UAS.cYa. Co-expression of tsg^Scer\UAS.cYa and sog^Scer\UAS.cYa under the control of Scer\GAL4^unspecified causes a strong synergistic wing phenotype.

(Yu et al., 2000)

Co-expression of one copy of sog^Scer\UAS.cYa strongly suppresses the wing phenotype caused by scw^Scer\UAS.cNa expressed under the control of Scer\GAL4^A9. Co-expression of four copies of sog^Scer\UAS.cYa has no effect on the wing phenotype caused by dpp^Scer\UAS.cHa expressed under the control of Scer\GAL4^A9.

(Nguyen et al., 1998)

An extra copy of dpp can rescue the wing vein defects of flies expressing sog^Scer\UAS.cYa under the control of Scer\GAL4^32B.

(Yu et al., 1996)

Xenogenetic Interactions

Statement

Reference

When expression of sog^Scer\UAS.cYa is driven by Scer\GAL4^A9 in combination with tsg^Scer\UAS.cYa, Hsap\TSG^Scer\UAS.cRa or Mmus\Tsg^Scer\UAS.cRa, gaps in the distal section of the wing veins occur.

(Ross et al., 2001)

Complementation and Rescue Data

Comments

Introduction of Dp(1;Y)sog⁺ rescues the wing vein L2 and anterior crossvein defect.

(Yu et al., 1996)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

sog^Scer\UAS.cYa

sog^UAS.cYa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Yu

(Yu et al., 1996)

Secondary FlyBase IDs

References (20)

Report Sections

Open Close