FB2024_04 , released June 25, 2024
Allele: Dmel\sog6
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General Information
Symbol
Dmel\sog6
Species
D. melanogaster
Name
FlyBase ID
FBal0015939
Feature type
allele
Associated gene
Dmel\sog
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Francois et al., 1994)

loss of function allele

(Biehs et al., 1996)
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Breakpoint in the 5' flanking sequences 2kb upstream of the transcription start site, perhaps separating sog from a necessary cis-regulatory element.

(Francois et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
sequence_alteration
X:15,628,440..15,628,640 [-]
Comment:

Reported to have a breakpoint approximately 2 kb upstream from the 5' end of the longest sog cDNA; the region from 1.9-2.1kb upstream is annotated.

(Francois et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Large sog6 mutant clones (generated by the FLP/FRT/Minute technique), that encompass both surfaces of the wing, disrupt the formation of the posterior crossvein (PCV). No other patterning defects are apparent in these wings. Smaller sog6 clones that encompass the central region of the PCV do not disrupt PCV formation.

      (Shimmi et al., 2005)

      Embryos heterozygous for sog6 show normal activation of Mad.

      (Eldar et al., 2002)

      Mutant embryos have a reduced number of amnioserosa cells.

      (Dorfman and Shilo, 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      sog6 is an enhancer of wing vein | ectopic phenotype of rhoMod

      (Yu et al., 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Significantly rescue haplo-insufficiency of dpp.

      (Francois et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sog6
      (Mizutani et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)