FB2024_03 , released June 25, 2024
Aberration: Dmel\In(2L)Cy
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General Information
Symbol
In(2L)Cy
Species
D. melanogaster
Name
Inversion (2L) Curly
FlyBase ID
FBab0004410
Feature type
chromosomal_inversion
Also Known As
In(2L+2R)Cy
Computed Breakpoints include

22D1-22D2;33F5-34A1

Sequence coordinates
2L:2,137,067..2,137,067 (In(2L)Cy:bk1)
(Miller et al., 2020)
2L:12,704,649..12,704,649 (In(2L)Cy:bk2)
(Miller et al., 2020)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
natural population
(Inoue and Igarashi, 1994, Ashburner and Lemeunier, 1976)
Class of aberration (relative to wild type)
chromosomal_inversion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_inversion
(Ashburner and Lemeunier, 1976)
Breakpoints

22D1-22D2;33F5-34A1

(Ashburner and Lemeunier, 1976)
Causes alleles
GlypCy
(Miller et al., 2020)
Carries alleles
Bl1
(The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
DuoxCy
(The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
b1
(The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
dpylvI
(The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
net1
(The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
pr1
(The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
Transposon Insertions
FB{}2LCy-dist
(Miller et al., 2020)
FB{}2LCy-prox
(Miller et al., 2020)
Formalized genetic data

bk1 << Su(S) << bk2

Genetic mapping information
Comments

Each breakpoint of In(2L)Cy is associated with an intact FB transposable element. No NOF elements are present at the breakpoints (these are often inserted into FB elements). The presence of the FB elements at each breakpoint, together with the detailed structure of the two elements suggests that In(2L)Cy may have arisen by recombination between two FB insertions; if this is the case, an FB insertion in GlyP (the distal breakpoint) is likely to have acted as the donor.

(Miller et al., 2020)

The 5' end of this breakpoint corresponds to 2L:12704649 and the 3' end corresponds to 2L:12704657 .

(Miller et al., 2020)

The 5' end of this breakpoint corresponds to 2L:2137067 and the 3' end corresponds to 2L:2137075 , in the 3'UTR of GlyP.

(Miller et al., 2020)

One or none of CG11723, TBCD or AIF may be affected by the 22D1 breakpoint.

(Miller et al., 2018)

The 5' (distal) genomic coordinate of the 22D1 breakpoint is unknown but has been mapped to the interval 2L:2 ,146,403-2,156,403 (release 6 coordinates). It is unknown if this breakpoint is associated with a duplication/deletion. The 3' (proximal) genomic coordinate of the 22D1 breakpoint is unknown but has been mapped to the interval 2L:2 ,146,403-2,156,403 (release 6 coordinates). It is unknown if this breakpoint is associated with a duplication/deletion.

(Miller et al., 2018)

The 5' (distal) genomic coordinate of the 33F4 breakpoint is unknown but has been mapped to the interval 2L:12 ,726,221-12,736,221 (release 6 coordinates). It is unknown if this breakpoint is associated with a duplication/deletion. The 3' (proximal) genomic coordinate of the 33F4 breakpoint is unknown but has been mapped to the interval 2L:12 ,726,221-12,736,221 (release 6 coordinates). It is unknown if this breakpoint is associated with a duplication/deletion.

(Miller et al., 2018)
Comments on Cytology

All limits from polytene analysis (FBrf0029349)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Glyp
(Miller et al., 2020)
MRP
(Miller et al., 2018)
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
CG5776
(Miller et al., 2020)
spict
(Miller et al., 2020)
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations
    NOT in combination with other aberrations

    Homozygous viable without Cy. Crossing over in In(2L)Cy/+ heterozygote greatly reduced in 2L (also see In(2R)Cy).

    Stocks (118)
    Notes on Origin
    Discoverer

    Ward, June 1921.

     

    In(2R)Cy

    (The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
    Balancer / Genotype Variants of the Aberration
    Separable Components
     
    Other Comments
     

    Used as a balancer in combination with In(2R)Cy.

    (The Moscow Regional Drosophila melanogaster Stock Center, Dubna)

    Quasi cosmopolitan inversion.

    (Inoue and Igarashi, 1994)

    In(2L)Cy and In(2R)Cy in heterozygous condition significantly increase the crossing over frequency in the proximal and distal regions of the X chromosome while in the middle of the chromosome crossing over frequency remains unaltered. The effect on interference remains unaltered at both ends of the X chromosome while a significant decrease is observed in the middle of the chromosome. Results suggest that the interchromosomal effect on crossing over affects the preconditions of exchange differently in different regions of the X chromosome and possibly the duration of chromosome pairing.

    (Portin and Rantanen, 1990)

    Exists with and without Cy1.

    Synonyms and Secondary IDs (7)
    References (20)